Effect of ethanolic extract of Olea europaea on Plasmodium falciparum infected mice
DOI:
https://doi.org/10.7439/ijbr.v5i6.654Abstract
Malaria persists as a major health burden in Africa in spite of all efforts at prevention and control. This study aimed at analyzing Olea europaea to establish its scientific basis in treating malaria. Thirty Swiss albino mice were divided into six groups of five rats each. Group A normal control (no induction, no treatment); group B experimental control (0.2 ml of O + human parasitized blood of Plasmodium falciparum induced but no treatment administered). Group C, D, and E were induced with Plasmodium falciparum intraperitoneally and treated with 40, 80 and 120 mg/kg body weight (bwt) ethanolic extract of the leaves of Olea europaea respectively . Malaria parasite was confirmed 72 hours after induction using a compound microscope. Group F was induced with the O + human parasitized ( Plasmodium falciparum ) blood and treated with a reference drug (Artesunate 50 mg/kg). Phytochemical screening of Olea europaea leaf plant extracts revealed high content of alkaloids, saponin, flavonoids, and cardiac glycosides. Proximate analysis of the Olea europaea leaf extract revealed 68.80% carbohydrate content, 10.60% moisture content, 37.00% crude fiber, 39.68% crude fat, 14.60% ash content. The 40 mg/kg, 80 mg/kg and 120 mg/kg bwt of the extract were able to inhibit 33.4%, 59.0% and 79.1% of parasitemia respectively. All infected animals had reduced packed cell volume following infection and increased with treatment. The dose 120 mg/kg bwt of Olea europaea extract was more potent compared to anti-malarial drug (artesunate 50 mg/kg). Hence, this extract and its components may be used as an antimalarial therapeutic agent.Downloads
Download data is not yet available.
Downloads
Published
2014-06-30
Issue
Section
Original Research Articles
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.
How to Cite
1.
Effect of ethanolic extract of Olea europaea on Plasmodium falciparum infected mice. Int Jour of Biomed Res [Internet]. 2014 Jun. 30 [cited 2024 Oct. 19];5(6):400-4. Available from: https://ssjournals.co.in/index.php/ijbr/article/view/1026