Phytochemical and Biological Evidences of Passiflora Incarnata Linn: A review
Keywords:
Passiflora Incarnata, chemical compounds, bioactivitiesAbstract
Passiflora incarnata from Passifloraceae family is an important medicinal plant of tropical and subtropical India. Its medicinal usage has been reported in the traditional systems of medicine such as Ayurveda, Siddha and Unani. P. incarnata has been described as a passion flower and has been used extensively for treatment of some diseases like as anxiety, insomnia, convulsion, sexual dysfunction, cough and cancer. A wide range of chemical compounds has been isolated, mainly alkaloids, flavonoids, phenols and carbohydrates. It has been described as passion flower and used extensively for treatment of several diseases like anxiety, insomnia, convulsion, sexual dysfunction, cough and cancer.
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References
Kinghorn GR. Passion, stigma, and STI. Sex Transm Inf 2001;77:370-5.
Dhawan K, Dhawan S, Sharma A. Passiflora: A review update. J Ethnopharmacol 2004;94:1-23.
Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: A pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7.
Reginatto FH, de-Paris F, Petry RD, Quevedo J, Ortega GG, Gosmann G, et al. Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species. Phytother Res 2006;20:348-51.
Wheatley D. Medicinal plants for insomnia: A review of their pharmacology, efficacy and tolerability. J Psychopharmacol 2005;19:414-21.
Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M. Passion flower in the treatment of opiates withdrawal: A double-blind randomized controlled trial. J Clin Pharm Ther 2001;26:369-73.
Ichimura T, Yamanaka A, Ichiba T, Toyokawa T, Kamada Y, Tamamura T, et al. Antihypertensive effect of an extract of Passiflora edulis rind in spontaneously hypertensive rats. Biosci Biotechnol Biochem 2006;70:718-21.
Rowe CA, Nantz MP, Deniera C, Green K, Talcott ST, Percival SS. Inhibition of neoplastic transformation of benzo [alpha] pyrene-treated BALB/c 3T3 murine cells by a phytochemical extract of passion fruit juice. J Med Food 2004;7:402-7.
Nassiri-Asl M, Shariati-Rad F, Zamansoltani F. Anticonvulsant effects of arial parts of Passiflora incarnata extract in mice: Involvement of benzodiazepine and opioid receptors. BMC Complement Altern Med 2007;7:26.
Kim, G.-H.; Lim, K.; Yang, H.S.; Lee, J.-K.; Kim, Y.; Park, S.-K.; Kim, S.-H.; Park, S.; Kim, T.-H.; Moon, J.-S.;et al. Improvement in neurogenesis and memory function by administration of Passiflora Incarnata L. extractapplied to sleep disorder in rodent models. J. Chem. Neuroanat. 2019, 98, 27–40.
Miroddi,M.; Calapai, G.; Navarra,M.;Minciullo, P.L.; Gangemi, S. Passiflora Incarnata L.: Ethnopharmacology,clinical application, safety and evaluation of clinical trials. J. Ethnopharmacol. 2013, 150, 791–804.
Kim,M.; Lim, H.-S.; Lee, H.-H.; Kim, T.-H. Role Identification of Passiflora Incarnata Linnaeus: AMini Review.J. Menopausal. Med. 2017, 23, 156–159.
P. Zanoli, R. Avallone and M. Baraldi. Behavioral characterisation of the flavonoids apigenin and chrysin. Fitoterapia. 71: S117–S123 (2000).
B. Glotzbach and H. Rimpler. Die Flavonoide von Passiflora incarnata L., Passiflora quadrangularis L. und Passiflora pulchella H.B.K. Planta Med. 16: 1-
(1968).
H. Schilcher. Zur Kenntnis der Flavon-C-Glykoside in Passiflora incarnata L. Z Naturforsch. 23: 1393 (1968).
J. Lohdefink. Untersuchungen zur Flavonoidfiihrung einiger Passiflora-Arten. Dtsch Apoth Ztg. 116: 557-560 (1976).
H. Geiger and K.R. Markham. The C-glycosylflavone pattern of Passiflora incarnata L. Z Naturforsch. 41C: 949-950 (1986).
L. Qimin, H. Van den Heuvel, O. Delorenzo, J. Corthout, L.A.C. Pieters, A.J. Vlietinck and M. Claeys. Mass spectral characterization of C-glycosidic flavonoids isolated from a medicinal plant (Passiflora incarnata). J Chromatogr. 562: 435-446 (1991).
A. Rehwald, B. Meier and O. Sticher. Qualitative and quantitative reversed-phase high-performance liquid chromatography of flavonoids in Passiflora incarnata L. Pharmaceutica Acta Helvetiae. 69: 153-158 (1994).
K. Rahman, L. Krenn, B. Kopp, Z.M. Schubert, K.K. Mayer and W. Kubelka. Isoscoparin-2’’-O-glucoside from P. incarnata. Phytochemistry. 45: 1093–1094 (1997).
E. Bennati. Quantitative determination of harman and harmine in Pincarnata extract. Bollettino Chimico Farmaceutico. 110: 664–669 (1971).
H. Tsuchiya, H. Hayashi, M. Sato, H. Shimiza and M. Iinuma.Quantitative analysis of all types of beta-carboline alkaloids in medicina plants and dried edible plants by high performance liquid chromatography with selective fluorometric detection. Phytochemica Analysis. 10: 247–253 (1999).
V.J. Lohdefink and H. Kating. Zur frage des vorkommens von harmanalkaloiden in Passiflora-arten. Planta Medica. 25: 101–104 (1974).
J. Lutomski and B. Nourcka. Simple carboline alkaloids. VI.Comparative chemical evaluation of alkaloid fractions from different sources. Herba Polanica. 14: 235–238 (1968).
A. Rehwald, O. Sticher and B. Meier. Trace analysis of Harman alkaloidin P. incarnata by reversed-phase high performance liquid chromatography. Phytochemical Analysis. 6: 96–100 (1995).
N. Aoyagi, R. Kimura and T. Murata. P. incarnata dry extract. Isolation of maltol and pharmacological action of maltol and ethyl maltol. Chemical and Pharmaceutical Bulletin. 22: 1008–1013 (1974).
N.M. Gavasheli, I.I. Moniava and L.I. Eristavi. Oligosaccharides of P. incarnata. Khimiya Prirodnykh Soedinenii. 11: 84–85 (1975).
G. Buchbauer and L. Jirovetz. Volatile constituents of the essential oil of
P. incarnata L. Journal of Essential Oil Research. 4: 329–334 (1992).
N.M. Gavasheli, I.I. Moniava and L.I. Eristavi. Flavonoids from P. incarnata. Khimiya Prirodnykh Soedinenii. 10: 95–96 (1974).
K.C. Spencer and D.S. Seigler. Gynocardin from Passiflora. Planta Medica. 51: 356–357 (1984).
D.M. Beaumont, T.M. Mark, R. Hills, P. Dixon, B. Veit and N. Garrett. The effects of chrysin, a Passiflora incarnata extract, on natural killer cell activity in male Sprague-Dawley rats undergoing abdominal surgery. AANA J. 76 (2): 113-17 (2008).
V.L. Benson, L.M. Khachigian and H.C. Lowe. DNAzymes and cardiovascular disease. British J Pharmacol. 154: 741–48 (2008).
K. Dhawan and A. Sharma. Antitussive activity of the methanol extract of Passiflora incarnata leaves. Fitoterapia. 73 (5): 397-99 (2002).
B.G. Katzung. Basic and clinical pharmacology. East Norwalk, Connecticut: Prentice-Hall International Inc, 306 (1992).
M. Nassiri-Asl, F. Shariati-Rad and F. Zamansoltani. Anticonvulsant effects of arial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. BMC Complementary and Alternative Medicine. 8: 2007.
K. Dhawan, S. Kumar and A. Sharma. Suppression of alcohol-cessation oriented hyper-anxiety by the benzoflavone moiety of Passiflora incarnata Linn. in mice. J Ethnopharmacol. 81 (2): 239-44 (2002).
Dhawan K, Kumar S, Sharma A. Antiasthmatic activity of the methanol extract of leaves of Passiflora incarnata. Phytother Res 2003;17:821-2.
Dhawan K, Kumar S, Sharma A. Aphrodisiac activity of methanol extract of leaves of Passiflora incarnata Linn in mice. Phytother Res 2003;17:401-3.
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