Estrogen and Estrogen Receptor a Risk Factor in Breast Cancer - A Review
Keywords:
Estrogen, Estrogen receptors, Sulfatase pathway, Aromatase pathway, TamoxifenAbstract
There are many evidences which shows that estrogens play a crucial role in the development of breast cancer. Most established risk factors for breast cancer in humans probably act through hormone-related pathways, and increased concentrations of circulating estrogens have been found to be strongly associated with increased risk for breast cancer in postmenopausal woman.
In this review we describe in detail estrogen metabolism and associated genetic variations, and provide a critical review of the current literature regarding the role of estrogens and their metabolites in breast cancer risk.
Estrogens display intriguing tissue selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast caner. Tamoxifen has been the only drug of choice for more than 30 years to treat patients with estrogen related (ER) positive breast tumor.
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