Estrogen and Estrogen Receptor a Risk Factor in Breast Cancer - A Review

Authors

  • Akanksha Saini SRM University, Delhi- NCR, Sonipat, Haryana, India
  • Kumar Utkarsh Shoolini University of Applied Sciences, Solan, Himachal Pradesh, India https://orcid.org/0000-0001-7483-0355
  • Neha SRM University, Delhi- NCR, Sonipat, Haryana, India
  • Anjali Priyadarshini Assistant Professor at SRM University, Delhi-NCR, Sonipat, Haryana, India

Keywords:

Estrogen, Estrogen receptors, Sulfatase pathway, Aromatase pathway, Tamoxifen

Abstract

There are many evidences which shows that estrogens play a crucial role in the development of breast cancer. Most established risk factors for breast cancer in humans probably act through hormone-related pathways, and increased concentrations of circulating estrogens have been found to be strongly associated with increased risk for breast cancer in postmenopausal woman.

In this review we describe in detail estrogen metabolism and associated genetic variations, and provide a critical review of the current literature regarding the role of estrogens and their metabolites in breast cancer risk.

Estrogens display intriguing tissue selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast caner. Tamoxifen has been the only drug of choice for more than 30 years to treat patients with estrogen related (ER) positive breast tumor.

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Published

2021-06-30

Issue

Vol. 12 No. 6 (2021): Jun

Section

Review Article

License

Copyright (c) 2021 International Journal of Biomedical and Advance Research

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How to Cite

Estrogen and Estrogen Receptor a Risk Factor in Breast Cancer - A Review. (2021). International Journal of Biomedical and Advance Research, 12(6), e5617. https://ssjournals.co.in/index.php/ijbar/article/view/5617