Comparative studies on Effect of Jadelle, Depoproveral and implanon Contraceptives on APOA1 and APO B Concentration in Females Attending a Tertiary Hospital in Southern Nigeria

Authors

  • Emmanuel Olugbenga Bamigbowu Department of Chemical Pathology, College of Medicine, University of Port Harcourt
  • Professor Samuel C. Meludu Department of Clinical Biochemistry, College of Medicine, Nnamdi Azikwe University Awka
  • Professor C.E. Dioka Department of Chemical Pathology, Nnamdi Azikwe University, Awka Nigeria
  • Adebayo Olugbenga Adegoke Department of Medical Laboratory Science, Madonna University

Keywords:

Implanon, Jadelle, Depo-provera, Apo A1, Apo B

Abstract

Background: Apolipoproteins function as structural components of lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors. Apo A1 a major component of high density lipoprotein, while Apo B which is a primary apolipoprotein of chylomicrons, VLDL, IDL, and LDL when in reference to both heart and vascular diseases indictment, helps in the transportation of fat molecules (lipids): cholesterol inclusive around the body. The study was carried out to compare Apo A1 and Apo levels in women on Implanon, Jadelle and Depo-Provera- the three most popular steroidal contraceptives used in south-south part of Nigeria.

Methodology: Ninety (90) female subjects in three groups of 30 each were recruited for Implanon, Jadelle and Depo-provera. Apo A1 and Apo B were determined using turbidimetric method on Baseline, 3rd, 6th, 9th and 12th month blood samples collected from these subjects.

Result: The result of the study showed that there was increased significant difference in Apo A concentration of females on Implanon, Jadelle and Depo-provera at 3rd, 6th, 9th and 12th months compared with the baseline. Also, a significant increased difference (P<0.05) was observed at the 3rd, 6th, 9th and 12th month in ApoB when compared with the baseline. A monthly dependent increase was observed in the three contraceptives studied for ApoB, a pattern which is also observed in ApoA1 in jadelle and depo-provera only.

Conclusion: The study showed that there were significant increased changes in Apo A1 and ApoB concentrations in female subjects taking Implanon, Jadelle and Depo-provera at different months.

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Published

2020-08-30

Issue

Vol. 11 No. 8 (2020): Aug

Section

Original Research Articles

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Copyright (c) 2020 International Journal of Biomedical and Advance Research

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How to Cite

Comparative studies on Effect of Jadelle, Depoproveral and implanon Contraceptives on APOA1 and APO B Concentration in Females Attending a Tertiary Hospital in Southern Nigeria. (2020). International Journal of Biomedical and Advance Research, 11(8), e5441. https://ssjournals.co.in/index.php/ijbar/article/view/5441