Effect of soy milk on alcohol induced liver disease in male albino Wistar rats

Abstract

The study was carried out to determine the effect of soymilk (soy extract) on alcoholic liver of male albino rats. Fifty four Male albino rats divided into six groups of 9 rats each were orally administered 20% alcohol, 20% alcohol and 25 mg/kg silymarine, 20% alcohol and 100 mg/kg of soymilk extract, 20% alcohol and 200mg/kg of soymilk extract and 20% alcohol and 400mg/kg of soymilk extract while the last group was fed water and rat diet ad libitum to serve as control for 28 days. The Aspartate aminotransaminase (AST), Alanine aminotransaminase (ALT), Alkaline Phosphatase (A LP), Total bilirubin, Direct bilirubin, Total Protein and albumin were determined using Colorimetric, Phenolphthalein Monophosphate by Jendrasik and Grof, Biuret and Bromocresol  by Green methods respectively. The result showed there was significant difference (P<0.05) in activities of AST (U/L) of 42.7±1.60, 84.0 ±3.86, 45.2±3.94 and 34.9±1.22, ALT (U/L) of 30.6±2.59, 105.6±6.36, 39.4±3.1 and 31.5 ±1.23 and ALP (U/L) of 55.5±3.20, 110.7±5.18, 78.9±6.16 and 65.6±2.33 in Control, Alcohol, Silymarine drug and Soy Extract respectively.  There was significant difference (P<0.05) in Total Bilirubin (umol/l) of 2.4±0.05, 3.0±0. 17, 2.6±0.15 and 2.41±0.05 while there was no difference (P>0.05) in Direct bilirubin (umol/l) of 1.4±0.75, 1.4±0.10, 1.3±0.08 and 1.25±0.03 in Control, Alcohol, Silymarine drug and Soy Extract respectively. There was no significant difference (P>0.05) in total protein (g/l) was 66.6±1.18, 64.7±2.55, 60.4±7.37 and 66.8±1.21 and albumin (g/l) of 33.7±1.35, 32.9±1.08, 34.1±0.92 and 35.7±0.54 in Control, Alcohol, Silymarine drug and Soy Extract respectively. The result obtained in the study suggested that Soymilk extract caused reversal to liver dysfunction caused by alcohol.