Malondialdehyde (MDA), a marker of oxidative stress in Beta Thalassemia major patients
Keywords:
Beta-thalassemia major, Oxidative stress, Malondialdehyde, FerritinAbstract
Background: The severe iron overload in beta thalassemia major patients leads to generation of free radicals and peroxidative tissue injury. This process is characterized by metabolic hyperproduction of reactive oxygen species (ROS) and induced lipid peroxidation (LPO). Malondialdehyde (MDA), a terminal compound of lipid peroxidation, is used widely as an index of oxidative status.
Method: serum MDA, iron, ferritin levels were measured in 49 beta thalassemia patients and were compared with age and gender matched 49 healthy individuals.
Result: The MDA level increased significantly in β thalassemia major patients (3.01±0.38) as compared to controls (1.68±0.2). Serum free iron, serum ferritin level was high in study group.
Conclusion: We conclude that in patients with β thalassemia, MDA is the marker of oxidative stress.
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