Formulation and Evaluation of Fast Dissolving Tablets of Meloxicam Using Superdisintegrants

Authors

  • Patil Prafulla Vasudeo Department of Pharmaceutics, Bhabha Pharmacy Research Institute, Bhabha University, Bhopal-462046, M.P., India
  • Ayush Pratap Singh Sengar Department of Pharmaceutics, Bhabha Pharmacy Research Institute, Bhabha University, Bhopal-462046, M.P., India
  • Raghuraj Lovanshi Department of Pharmaceutics, Bhabha Pharmacy Research Institute, Bhabha University, Bhopal-462046, M.P., India
  • Om Prakash Agrawal Department of Pharmaceutics, Bhabha Pharmacy Research Institute, Bhabha University, Bhopal-462046, M.P., India

Keywords:

Meloxicam, Fast Dissolving Tablets, Superdisintegrants, Crospovidone, β-Cyclodextrin, Sublimation

Abstract

Fast Dissolving Tablets (FDTs) have gained significant attention due to their convenience, rapid onset of action, and suitability for dysphagic patients. Meloxicam, a BCS Class II drug, suffers from poor aqueous solubility and delayed onset when administered through conventional tablets. The present study aims to formulate and optimize Meloxicam FDTs using various superdisintegrants, including Sodium CMC, Crospovidone, Kyron T-314, and β-Cyclodextrin, with menthol sublimation employed to enhance porosity. Tablets were prepared using the direct compression method and evaluated for pre-compression parameters, post-compression characteristics, disintegration time, and in-vitro drug release. Among all formulations, batch F9 (containing Crospovidone + β-Cyclodextrin) exhibited the fastest disintegration time (≈9 seconds) and highest cumulative drug release (≈99.88% within 10 minutes). The optimized formulation outperformed the marketed tablet across all evaluation parameters. Thus, Meloxicam FDTs prepared with Crospovidone and β-Cyclodextrin provide a reliable, fast-acting, and patient-friendly alternative to conventional dosage forms.

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Published

2025-12-02

Issue

Vol. 14 No. 1 (2025)

Section

Research Articles

License

Copyright (c) 2025 International Journal of Advances in Pharmaceutics

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How to Cite

1.
Formulation and Evaluation of Fast Dissolving Tablets of Meloxicam Using Superdisintegrants. Int J Adv Pharm [Internet]. 2025 Dec. 2 [cited 2026 Jan. 3];14(1):e5884. Available from: https://ssjournals.co.in/index.php/ijap/article/view/5884