Eenhancement of solubility and dissolution rate of Furosemide by ternary solid dispersion technique

Abstract

Purpose: This investigation was carried out to determine if a solid dispersion of furosemide in different carrier such as poloxamer 407P, PEG 6000, and PVPK30 would enhance the dissolution properties of the drug. Method: Solid dispersion of drug Furosemide, PEG 6000 and Poloxamer 407 and PVP K30 were prepared with a view to study the influence of polymer on solubility and dissolution of this poorly soluble drug furosemide. Solid dispersions of furosemide were prepared using different ratios of furosemide, PEG 6000, Poloxamer 407, pvpk30 as carrier by, solvent evaporation method. They were evaluated for percentage yield, drug content, FTIR spectral studies, DSC, XRD, solubility, and in-vitro dissolution. The dissolution studies were performed at 37 0.5^oC and 50 rpm in simulated gastric fluid (0.1 N HCl). Result: The solubility profile indicated that there is increase in solubility of furosemide when polymer concentration is increased. The solid dispersion complex of drug (1:4:4 ratios) of drug: poloxamer 407: pvpk30 was giving better dissolution profile as compared to pure drug and other solid dispersions. This in turn can improve the bioavailability. FT-IR, DSC shows the compatibility of drug and carrier. Conclusion: Solid dispersion technique can be used to improve the dissolution of furosemide.