Phytochemical and pharmacological evaluation of Artocarpus Philippinensis Lam. for anthelmintic activity
Keywords:
Artocarpus Philippinensis LAM, Albendazole, Pheretima posthuma, Anthelmintic, Egg Hatch TestAbstract
In the current in vitro study, 10 mg/ml concentration of ethanolic extract of Artocarpus Philippinensis (Jackfruit) produced a statistically significant anthelmintic activity that is comparable with the conventional anthelmintic agent, Albendazole. This finding is additionally in line with the clinical study that confirmed the efficacy of the plant against nematodes in calves and superior to an in vitro study that reported a moderate level of anthelmintic activity from the rind of A. heterophyllus. A. heterophyllus, is mainly used as an anthelmintic agent in traditional practice. Concordant with this, in EHIA of the present study, ethanolic extract of Artocarpus Philippinensis LAM fruit induced a significant egg hatching inhibition of 98.67%, at 1 mg/ml concentration. In which fruit extracts are used as an anthelmintic in Pheretima posthuma infestation of sheep. Furthermore, the genus is a rich source of sesquiterpene lactones and flavonoids that might have anthelmintic activity with low risk of mammalian toxicity.
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