Comparative evaluation of efficacy and safety of lurasidone & olanzapine in patients of schizophrenia: A randomized, parallel group clinical study
Keywords:
lurasidone, schizophrenia, olanzapineAbstract
Background: Since very few studies were available in Indian population about efficacy, safety of lurasidone versus olanzapine, so these were compared in this trial.
Objective: To compare the efficacy and safety of lurasidone with olanzapine in the treatment of schizophrenia and study the adverse effects of lurasidone.
Materials and Methods: Sixty-four schizophrenic patients were recruited into one of the assigned groups for random allocation to olanzapine or lurasidone (n=32 in each group) in open- label, 12 week clinical trial and their guardians informed consent was taken. PANSS (positive and negative syndrome scale) was used as the primary outcome measure and Clinical Global Impression Severity Score (CGI-S) was employed as secondary scale.
Results: Within‑group analysis both of olanzapine and lurasidone were significantly effective for improvement of PANSS total score and CGI-S (P < 0.0001). But in between-group analysis there is statistically significant reduction in PANSS total score (P < 0.001) and CGI-S score (P < 0.0001) in lurasidone group than olanzapine.
Conclusion: Lurasidone is superior to olanzapine in efficacy and safety in patients of schizophrenia. Lipid profile and blood sugar monitoring should be done in patients on long‑term olanzapine therapy.
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