Evaluation of the prescription of psychotropic drugs and their potential drug interactions at the Jamot Hospital in Yaoundé-Cameroon
Keywords:
Psychotropic drugs, Potential drug interactions, Medscape, DrugbankAbstract
Objective: To assess the compliance of medical prescriptions containing psychotropic drugs and potential drug interactions.
Methods: This descriptive cross-sectional study was conducted at Jamot Hospital in Yaoundé (Cameroon) from March to May 2018. Medical prescriptions were collected consecutively at the hospital's in-house pharmacy, and only those containing at least one psychotropic drug were retained. The date, the identity of the prescriber and the patient, as well as information about the medication were searched. Potential drug interactions were analysed using two drug interaction checking software programs: Medscape and Drugbank.
Results: One hundred and thirty-four (134) prescriptions were collected and 20 (14.92%) contained at least one psychotropic drug and all were written on simple prescriptions. The following were present: date (100%), registration number in the National Order of Doctors in Cameroon (25%), prescriber's address (30%), patient's name (95%), age (65%), sex (35%), weight (0%), dosage (85%), galenic form (90%), unit of intake (90%), frequency of intake (85%), duration of treatment (l0%), mention of "to be renewed or not" (1%). Almost 80% of the prescriptions contained at least 3 potential drug interactions, of which 72.88% were pharmacodynamic and 27.11% pharmacokinetic. The potential drug interactions identified were type C (91.52%), D (5.08%) and B (3.39%).
Conclusion: None of the prescriptions complied with the rules for prescribing psychotropic drugs and almost all the potential drug interactions identified were moderate.
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