Prevalence of potential drug-drug interactions in post-operative patients at tertiary care hospital using Lexicomp drug interaction software

Authors

  • Dr. Vikas Pt. BD Sharma Post Graduate Institute of Medical Sciences( PGIMS) Rohtak, Haryana, India
  • Dr. Niti Mittal Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India
  • Dr Rashi Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India https://orcid.org/0000-0003-1102-2902
  • Dr Manoj Kumar Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India
  • Dr Rakesh Mittal Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India
  • Dr Shweta Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India

Keywords:

Drug Drug Interactions, Post-operatice Patients, Antimicrobial Utilization, Lexicomp

Abstract

Potential drug-drug interactions (pDDIs) contribute to the development of adverse drug reactions, prolonged hospitalization and economic burden of patient. Preventing drug interactions is an important goal to maximize patient benefit from medications. Post-operative patients are very commonly prescribed with antimicrobials, analgesics and gastric acid lowering drugs. These drugs are very prone to have pDDIs. The aim of this study was to find prevalence of pDDIs in post-operative patients using Lexicomp drug interaction checking software. This was a retrospective observational study conducted in 305 patients. The drug interactions were divided into A, B, C, D, X categories with increase in severity from A to X. Total of 130 drug interactions were identified in these 50 prescriptions out of 305. Maximum drug interactions were in category C (48%) followed by category B (23%) and category X (20%). Antimicrobials constituted 52 out of 130 pDDIs. Amongst antimicrobials, category X had maximum (40 %) pDDIs. Many drug interactions can easily be avoided using various drugs interaction software available. According to the results, the use of programs like Lexicomp, for the determination of pDDIs is recommended in the clinical practice in order to prevent avoidable adverse effects.

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Author Biographies

  • Dr. Niti Mittal, Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India
    Assistant Professor, MD, DM, Department of Pharmacology, PGIMS, Rohtak
  • Dr Rashi, Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India
    Post graduate, Department of Community Medicine, PGIMS, Rohtak
  • Dr Manoj Kumar, Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India
    Post graduate, Department of Anaesthesiology and critical care, PGIMS, Rohtak
  • Dr Rakesh Mittal, Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India
    Professor, Department of Pharmacology, PGIMS, Rohtak
  • Dr Shweta, Pt. BD Sharma Post Graduate Institute of Medical Sciences (PGIMS) Rohtak, Haryana, India
    Post graduate, Department of Anaesthesiology and critical care, PGIMS, Rohtak

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Published

2021-05-30

Issue

Vol. 11 No. 5 (2021): May

Section

Research Articles

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How to Cite

1.
Dr. Vikas, Mittal DN, Dr Rashi, Kumar DM, Mittal DR, Dr Shweta. Prevalence of potential drug-drug interactions in post-operative patients at tertiary care hospital using Lexicomp drug interaction software. Int J of Pharmc Res [Internet]. 2021 May 30 [cited 2025 Mar. 14];11(5):e5600. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/5600