Determination of antidepressant activity of cinnamaldehyde per se and its interaction with escitalopram using tail suspension test in swiss albino mice
Keywords:
TCADs, SSRI, BDF, Neurotic disorder, Neurotransmitter.Abstract
Cinnamon is one of the best-known spices used as an herbal medicine. Cinnamaldehyde (CNM) is the most important constituents of cinnamon.
Objectives : The present study was aimed to evaluate the antidepressant activity of CNM per se & its interaction with standard antidepressant drug, escitalopram in Swiss albino mice using tail suspension method.
Method : Healthy mice of either sex weighing 20-30 grams were divided into groups of 6 animals each. For this CNM (100, 200 & 400 mg/kg), escitalopram 10 mg/kg & combination (CNM 100/200 mg/kg + escitalopram 10 mg/kg) were given orally daily for 21 days. TST was done on 1st, 7th, 14th, & 21st day.
Results : On acute administration escitalopram as well as CNM at lower doses i.e.100mg/kg showed the antidepressant activity as compared to control. (p< 0.05) however at higher doses of 200 & 400 mg/kg CNM did not show any effect. While on sub acute and chronic administration of CNM for 14 and 21 days respectively, CNM (100 mg/kg) has antidepressant activity (p< 0.05), while increasing doses of 200 and 400 mg/kg did not change any time of immobilisation significantly as compared to control but when CNM 200mg/kg was given in combination with escitalopram 10mg/kg, decrease in the antidepressant effect of escitalopram was observed.
Conclusions : CNM at lower dose alone as well as in combination with escitalopram showed antidepressant activity in both acute and chronic study while at higher dose i.e. 200/400 mg/kg did not. But combination of CNM 200mg/kg with escitalopram showed decrease in the antidepressant effect only on chronic administration.
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References
Nature and sources of drugs. In: Sharma HL and Sharma KK editors. Principles of Pharmacology, 1st ed. Hyderabad, India: Paras Medical Publishers; 2007. p.6-8.
Nature and sources of drugs. In: Sharma HL and Sharma KK editors. Principles of Pharmacology, 1st ed. Hyderabad, India: Paras Medical Publishers; 2007. p.4.
Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36. https://pubmed.ncbi.nlm.nih.gov/11506060/
Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 2003;66:1022-37. https://pubmed.ncbi.nlm.nih.gov/12880330
Newman DJ, Cragg GM, Snader KM. The influence of natural products upon drug discovery. Nat Prod Rep. 2000;17(3):215-34. https://pubmed.ncbi.nlm.nih.gov/10888010
Lai PK and Roy J. "Antimicrobial and chemopreventive properties of herbs and spices". Curr. Med. Chem. 2004;11(11):1451–60. https://pubmed.ncbi.nlm.nih.gov/15180577/
Tapsell LC, Hemphill I, Cobiac L, Patch CS, Sullivan DR, Fenech M et al. "Health benefits of herbs and spices: the past, the present, the future". Med. J. Aust. 2006;185(S4):S4-24. https://pubmed.ncbi.nlm.nih.gov/17022438/
Ram A, Lauria P, Gupta R, Kumar P, Sharma VN. Hypocholesterolaemic effects of Terminalia arjuna tree bark. J Ethnopharmacol 1997;55(3):165-9. https://pubmed.ncbi.nlm.nih.gov/9080336/
Wang F.a • Pu C.a • Zhou P.a • Wang P.a • Liang D.a • Wang Q.a • Hu Y.b • Li B.c • Hao X.d
Wang F, Pu C, Zhou P, Wang P, Liang D, Wang Q et al. Cinnamaldehyde Prevents Endothelial Dysfunction Induced by High Glucose by Activating Nrf2. Cell Physiol Biochem 2015;36(1):315-24. https://pubmed.ncbi.nlm.nih.gov/25967970/
Xue YL, Shi HX, Murad F and Bian K. Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta. Vasc Health Risk Manag. 2011; 7: 273–280. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096507/
Fabricant DS and Farnsworth NR. "The value of plants used in traditional medicine for drug discovery". Environ. Health Perspect. 2001;109(1):69–75. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240543/
Cox PA. Ethnopharmacology and the search for new drugs. Ciba Found Symp. 1990;154:40-7. https://pubmed.ncbi.nlm.nih.gov/2086040/
Cox P and Balick M. The ethnobotanical approach to drug discovery. J Sci Am.1994:270(6):82-87. https://pubmed.ncbi.nlm.nih.gov/8023119/
Vogel HG editor. Drug discovery and evaluation : Phamacological essays. 2nded. New York: Springer-Verlag Berlin Heidelberg; 2002. p. 561.
Kamej J, Miyata S, Morita K, Saitoh A, Takeda H. Effects of selective serotonin reuptake inhibitors on the immobility time in tail suspension test in streptozotocin induced diabetic mice. Pharmacol Biochem Behav 2003;75:247-254. https://pubmed.ncbi.nlm.nih.gov/12873612/
Moura JC de, Noroes MM, Rachetti V de PS, Soares BL, Preti D, Nassini R. et al. The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice. Brjpharmacol 2014;171(18):4289–99. https://pubmed.ncbi.nlm.nih.gov/24846744/
Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 1985;85(3):367-70. https://pubmed.ncbi.nlm.nih.gov/3923523/
Jana A, Modi KK, Roy A, Anderson JA, Breemen VRB, Pahan K. Up-regulation of neurotrophic factors by cinnamon and its metabolite sodium benzoate : Therapeutic implications for neurodegenerative disorders.J Neuroimmune Pharmacol. 2013;8(3):739–55. https://europepmc.org/article/med/23475543/
Hong JW, Yang G, Kim YB, Eom SH, Lew JH, Kang H. ‘Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models’. BMC Complement Altern Med. 2012;12:237. https://pubmed.ncbi.nlm.nih.gov/23190501/
Lee HB and Kim YK. ‘The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment’. Psychiatry Investig. 2010;7(4): 231–35. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022308/
Tu WZ, Wu F, Yan QZ, Yang XZ, Lin Z, Xu Z et al. Protective effect of proanthocyanidins on depression and anxiety behaviour in chronically stressed rats. Chinese journal of pharmacology and toxicology. 2014;28(3).345-50. https://www.researchgate.net/publication/287265820
Martinowich, K. and Lu, B. ‘Interaction between BDNF and Serotonin : Role in Mood Disorders’. Neuropsychopharmacology 2008;33(1):73-83. https://pubmed.ncbi.nlm.nih.gov/17882234/
Parisa N, Kamaluddin MT, Theodorus T. The Efficacy of Cinnamomum burmannii Extract on the Protection of Neuronal Cell Death in Haloperidol Induced Male Wistar Rats.
Bio Sc Med 2(4):1-11. https://pdfs.semanticscholar.org/5c8a/0b3616361e7aea69846b497d51627a88c313.pdf?_
Więdłocha M, Marcinowicz P, Krupa R, Janoska-Jaździk M, Janus M, Dębowska W et al.
Effect of antidepressant treatment on peripheral inflammation markers - A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 2018;80(Pt C):217- 26. https://pubmed.ncbi.nlm.nih.gov/28445690/
Bal N, Acar ST, Yazıcı A, Yazıcı K, Tamer L. Altered Levels of Malondialdehyde and Vitamin E in Major Depressive Disorder and Generalized Anxiety Disorder. Journal of Psychiatry & Neurological Sciences 2012;25: 206–11. https://dusunenadamdergisi.org/storage/upload/pdfs/1586259161-en.pdf
Sahin C, Dursun S, Cetin M, Aricioglu F. The Neuroinflammation Perspective of Depression : Reuniting the Outstanding Mechanisms of the Pathophysiology. Bulletin of Clinical Psychopharmacology 2016; 26(2):1. https://www.researchgate.net/publication/303668641_
Rao PV, and Gan SH. (2014) ‘Cinnamon : A Multifaceted Medicinal Plant’. Evidence-Based Complementary and Alternative Medicine 2014. http://dx.doi.org/10.1155/2014/642942.
Felice LJD. A current view of serotonin transporters. F1000Res. 2016; 5:F1000FacultyRev–1884. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965693/
Dhiman P, Malik N, Khatkar A. Lead optimization for promising monoamine oxidase inhibitor from eugenol for the treatment of neurological disorder : synthesis and in silico based study. BMC Chemistry 2019;13:38. https://bmcchem.biomedcentral.com/articles/10.1186/s13065-019-0552-4.
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