Effect of tamoxifen on ethanol induced gastric ulcer in rats
Keywords:
Tamoxifen, ulcer, anti-oxidants, cytoprotectiveAbstract
Background: Tamoxifen is selective estrogen receptor modulators, used in treatment of breast cancer; some literatures reported its impact on the process of peroxidation.
Aim: This study was aimed to evaluate the effect of tamoxifen on ethanol induced gastric ulcer in rats.
Method: Gastric ulcers were induced in Wistar albino rats by oral administration of absolute alcohol (1 ml/200 gm). Antiulcer activity of tamoxifen (0.5 and 10 mg/kg, p.o.) was observed and compared to standard drug (omeprazole 20mg/kg, p.o.), the ulcer index, ulcers numbers, lengths, gastric volume and total gastric acidity were evaluated. Histopathology is performed for confirmation.
Results: tamoxifen in 10mg/kg dose produced a highly significant (P<0.001) decrease in ulcer parameters studied compared to ulcer control. While 0.5mg/kg of tamoxifen produced less significant (P<0.01) effect on gastric volume when compared to ulcer group. The anti-ulcer effects of the drug of interest is highly comparable to omeprazole was very, surprisingly; the higher dose of tamoxifen produced even a much significant reduction in gastric volume and ulcers length compared to standard drug.
Conclusion: Tamoxifen shows significant antiulcer activity against ethanol induced gastric ulcers, and this could possibly related to its antioxidant properties.
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