Effect of tamoxifen on ethanol induced gastric ulcer in rats

Authors

  • Malak Eljafari Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli. Tripoli, Libya. https://orcid.org/0000-0002-5361-6293
  • al-attar Department of Pathology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Keywords:

Tamoxifen, ulcer, anti-oxidants, cytoprotective

Abstract

Background: Tamoxifen is selective estrogen receptor modulators, used in treatment of breast cancer; some literatures reported its impact on the process of peroxidation.

Aim: This study was aimed to evaluate the effect of tamoxifen on ethanol induced gastric ulcer in rats.

Method: Gastric ulcers were induced in Wistar albino rats by oral administration of absolute alcohol (1 ml/200 gm). Antiulcer activity of tamoxifen (0.5 and 10 mg/kg, p.o.) was observed and compared to standard drug (omeprazole 20mg/kg, p.o.), the ulcer index, ulcers numbers, lengths, gastric volume and total gastric acidity were evaluated. Histopathology is performed for confirmation.

Results: tamoxifen in 10mg/kg dose produced a highly significant (P<0.001) decrease in ulcer parameters studied compared to ulcer control. While 0.5mg/kg of tamoxifen produced less significant (P<0.01) effect on gastric volume when compared to ulcer group. The anti-ulcer effects of the drug of interest is highly comparable to omeprazole was very, surprisingly; the higher dose of tamoxifen produced even a much significant reduction in gastric volume and ulcers length compared to standard drug.

Conclusion: Tamoxifen shows significant antiulcer activity against ethanol induced gastric ulcers, and this could possibly related to its antioxidant properties.

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Published

2021-02-28

Issue

Vol. 11 No. 2 (2021): Feb

Section

Research Articles

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How to Cite

1.
Eljafari M, R. Al-Attar A-A. Effect of tamoxifen on ethanol induced gastric ulcer in rats. Int J of Pharmc Res [Internet]. 2021 Feb. 28 [cited 2025 Mar. 14];11(2):e5555. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/5555