Effect of Artocarpus Heterophyllus Phenolic Seed Extract In Animal Models Of Depression: A Preclinical Study
Keywords:
Artocarpus heterophyllus, anti-depressants, Forced Swimming Test and Tail Suspension TestAbstract
Background: The jackfruit (Artocarpus heterophyllus Lam.) is an integral part of common Indian diet. The present study was carried out to elucidate the possible antidepressant activity of jack fruit in Swiss albino mice.
Objective: To evaluate the possible antidepressant activity of Artocarpus heterophyllus seed extract in Swiss albino mice.
Methodology: A total of 30 (n=30) Male Swiss albino mice weighing 25-35 g, divided into five groups of six animals each was used for the study. Artocarpus heterophyllus (Jackfruit) collected grinded and crushed well and uniformly. Powder was subjected to solvent extraction with phenol in a soxhlet apparatus. Antidepressant activity of phenolic extract of A. heterophyllus seeds was evaluated by using two models –Forced Swimming Test (FST) and Tail Suspension Test (TST).
Results: One way ANOVA was used for multiple comparisons followed by post hoc (bonferroni test) for comparison between groups. Artocarpus heterophyllus (Jackfruit) at the dose of 200 mg/kg significantly reduced the immobility time in both the tests (TST and FST) compared to the control. The reduction in duration of immobility at the dose of 200 mg/kg was comparable to the standard drug Imipramine.
Conclusion: The phenolic extract of seeds of Artocarpus heterophyllus has significant antidepressant activity in both the animal models of depression (FST and TST).
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