Neuro-protective effect of Suramin against aluminum-induced cognitive dysfunction in rats

Authors

  • Angad M. Patole Department of Pharmacology, Institute of Pharmaceutical Education and Research, Boragon (Meghe), Wardha, Maharastra
  • Pournima Adhaoo Department of Pharmacology, Institute of Pharmaceutical Education and Research, Boragon (Meghe), Wardha, Maharastra
  • Sunil P. Dewani Department of Pharmacology, Institute of Pharmaceutical Education and Research, Boragon (Meghe), Wardha, Maharastra
  • Jyotiranjan Raul Department of Pharmacology, Institute of Pharmaceutical Education and Research, Boragon (Meghe), Wardha, Maharastra
  • Bhushan R Gandhare Associate Professor, Institute of Pharmaceutical Education and Research, Borgaon(Meghe), Wardha https://orcid.org/0000-0003-1726-2149

Keywords:

Alzheimer's disease, Excitotoxicity, Suramin, physostigmine

Abstract

Suramin is N-methyl-D-aspartate (NMDA) receptor antagonist which protects against the glutamate excitotoxicity and oxidative stress. Aluminum is a potent neurotoxin involved in the initiation and progression of various cognitive disorders like Alzheimer's disease (AD). Chronic aluminum exposure induces glutamate excitotoxicity, oxidative stress and increases amyloid beta levels in vivo. Therefore, the present study was designed to explore the possible role of suramin against aluminum mediating cognitive dysfunction in rats. Aluminum chloride (100 mg/kg, i.p.) was given to rats daily for 30 days to induce cognitive dysfunction. Suramin (25, 50 and 100 mg/kg, i.v.) and physostigmine (0.50 mg/ kg i.p.) was given for 30 days along with aluminium treatment. On the 31st day of the study, various behavioral tests (radial arm maze and elevated plus maze task paradigms) were done to evaluate cognitive tasks. According to the study chronic aluminum chloride administration resulted in poor retention of memory in radial arm maze and elevated plus maze task paradigms. Chronic administration of suramin significantly improved memory retention tasks in aluminum-treated rats. The study advocates a cognitive enhancing effect of suramin against aluminum-induced cognitive dysfunction.

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Published

2020-04-30

Issue

Vol. 10 No. 4 (2020): Apr

Section

Research Articles

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Copyright (c) 2020 International Journal of Pharmacological Research

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How to Cite

1.
Patole AM, Adhaoo P, Dewani SP, Raul J, Gandhare BR. Neuro-protective effect of Suramin against aluminum-induced cognitive dysfunction in rats. Int J of Pharmc Res [Internet]. 2020 Apr. 30 [cited 2025 Jul. 22];10(4):e5406. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/5406