Medical management of endometriosis
Abstract
Endometriosis is a chronic and benign gynecological disorder affecting women of reproductive age group. This chronic disease has a negative impact on the quality of life of women by causing symptoms like chronic pelvic pain, severe dysmenorrhoea, dyspareunia and infertility. Given a 10%-20% prevalence rate among women of reproductive age, it contributes to more than 100,000 hysterectomies worldwide each year. Aithough a number of medical managements are available at present but most of these produces adverse effects like induction of a hypo-estrogenic state, which further enhances infertility and unwanted menopausal-like side effects. Furthermore, recurrence of symptoms is common during treatment-free intervals. These major drawbacks of current treatments often lead to abandonment of medical therapy and calls for repeated surgical therapy. Present review article is an evaluation of currently available options and advances in medical interventions.Downloads
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References
REFERENCES
1. Carlson KJ, Miller BA, Fowler FJ Jr. The Maine Women's Health Study: I. Outcomes of hysterectomy. Obstet Gynecol 1994; 83: 556-65.
2. Falcone T, Hurd, William W. Clinical Reproductive Medicine and Surgery. Philadelphia: Mosby Elsevier, 2007.
3. Descamps P, Andreeva E, Leng J, Salehpour S, Chapron C. The place of gonadotropin-releasing hormone agonists in the management of endometriosis. J Endometr Pelvic Pain Disord. 2014 Feb 10; 6(1):1–11.
4. E. S. Surrey, “Gonadotropin-releasing hormone agonist and add-back therapy: what do the data show?” Current Opinion in Obstetrics and Gynecology2010; 22:283–288.
5. Crosignani P, Olive D, Bergqvist A, Luciano A. Advances in the management of endometriosis: an update for clinicians. Hum Reprod Update. 2006 Apr; 12(2):179–89.
6. A. Y. Wong, L. C. Tang, and R. K. Chin, “Levonorgestrelreleasing intrauterine system (Mirena) and Depotmedroxyprogesterone acetate (Depoprovera) as long-term maintenance therapy for patients with moderate and severe endometriosis: a randomised controlled trial,” Australian and New Zealand Journal of Obstetrics and Gynaecology 2010; 20: 273–279.
7. P. Vercellini, B. Eskenazi, D. Consonni et al., “Oral contraceptives and risk of endometriosis: a systematic review and metaanalysis,” Human Reproduction Update, vol. 17, no. 2, Article ID dmq042, pp. 159–170, 2011.
8. Strowitzki T, Marr J, Gerlinger C, Faustmann T, Seitz C. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, openlabel trial. Hum Reprod 2010; 25:633-41.
9. Berlanda N, Somigliana E, Frattaruolo MP, Buggio L, Dridi D, et al. Surgery versus hormonal therapy for deep endometriosis: is it a choice of the physician? Eur J Obstet Gynecol Reprod Biol 2017; 209: 67-71.
10. Angioni S, Nappi L, Pontis A, Sedda F, Luisi S, et al. Dienogest. A possible conservative approach in bladder endometriosis. Results of a pilot study. Gynecol Endocrinol 2015; 31(5): 406-408.
11. Amsterdam LL, Gentry W, Jobanputra S, Wolf M, Rubin SD, Bulun SE. Anastrazole and oral contraceptives: a novel treatment for endometriosis. Fertil Steril 2005; 84: 300-4.
12. A. G. Ricci, C. N. Olivares, M. A. Bilotas, G. F. Meresman, and R. I. Bara˜nao, “Effect of vascular endothelial growth factor inhibition on endometrial implant development in a murine model of endometriosis,” Reproductive Sciences2011; 18(7):614–622.
13. Barrier BF, Bates GW, Leland MM, Leach DA, Robinson RD, Propst AM. Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons. Fertil Steril 2004; 81 Suppl 1: 775-9.
14. H. Kamencic and J. A. Thiel, “Pentoxifylline after conservative surgery for endometriosis: a randomized, controlled trial,” Journal of Minimally Invasive Gynecology2008; 15(1):62–66.
15. K. Chwalisz, K. Mattia-Goldberg, M. Lee, W. Elger, and A. Edmonds, “Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil,” Fertility and Sterility2004; 82:S83–S84.
1. Carlson KJ, Miller BA, Fowler FJ Jr. The Maine Women's Health Study: I. Outcomes of hysterectomy. Obstet Gynecol 1994; 83: 556-65.
2. Falcone T, Hurd, William W. Clinical Reproductive Medicine and Surgery. Philadelphia: Mosby Elsevier, 2007.
3. Descamps P, Andreeva E, Leng J, Salehpour S, Chapron C. The place of gonadotropin-releasing hormone agonists in the management of endometriosis. J Endometr Pelvic Pain Disord. 2014 Feb 10; 6(1):1–11.
4. E. S. Surrey, “Gonadotropin-releasing hormone agonist and add-back therapy: what do the data show?” Current Opinion in Obstetrics and Gynecology2010; 22:283–288.
5. Crosignani P, Olive D, Bergqvist A, Luciano A. Advances in the management of endometriosis: an update for clinicians. Hum Reprod Update. 2006 Apr; 12(2):179–89.
6. A. Y. Wong, L. C. Tang, and R. K. Chin, “Levonorgestrelreleasing intrauterine system (Mirena) and Depotmedroxyprogesterone acetate (Depoprovera) as long-term maintenance therapy for patients with moderate and severe endometriosis: a randomised controlled trial,” Australian and New Zealand Journal of Obstetrics and Gynaecology 2010; 20: 273–279.
7. P. Vercellini, B. Eskenazi, D. Consonni et al., “Oral contraceptives and risk of endometriosis: a systematic review and metaanalysis,” Human Reproduction Update, vol. 17, no. 2, Article ID dmq042, pp. 159–170, 2011.
8. Strowitzki T, Marr J, Gerlinger C, Faustmann T, Seitz C. Dienogest is as effective as leuprolide acetate in treating the painful symptoms of endometriosis: a 24-week, randomized, multicentre, openlabel trial. Hum Reprod 2010; 25:633-41.
9. Berlanda N, Somigliana E, Frattaruolo MP, Buggio L, Dridi D, et al. Surgery versus hormonal therapy for deep endometriosis: is it a choice of the physician? Eur J Obstet Gynecol Reprod Biol 2017; 209: 67-71.
10. Angioni S, Nappi L, Pontis A, Sedda F, Luisi S, et al. Dienogest. A possible conservative approach in bladder endometriosis. Results of a pilot study. Gynecol Endocrinol 2015; 31(5): 406-408.
11. Amsterdam LL, Gentry W, Jobanputra S, Wolf M, Rubin SD, Bulun SE. Anastrazole and oral contraceptives: a novel treatment for endometriosis. Fertil Steril 2005; 84: 300-4.
12. A. G. Ricci, C. N. Olivares, M. A. Bilotas, G. F. Meresman, and R. I. Bara˜nao, “Effect of vascular endothelial growth factor inhibition on endometrial implant development in a murine model of endometriosis,” Reproductive Sciences2011; 18(7):614–622.
13. Barrier BF, Bates GW, Leland MM, Leach DA, Robinson RD, Propst AM. Efficacy of anti-tumor necrosis factor therapy in the treatment of spontaneous endometriosis in baboons. Fertil Steril 2004; 81 Suppl 1: 775-9.
14. H. Kamencic and J. A. Thiel, “Pentoxifylline after conservative surgery for endometriosis: a randomized, controlled trial,” Journal of Minimally Invasive Gynecology2008; 15(1):62–66.
15. K. Chwalisz, K. Mattia-Goldberg, M. Lee, W. Elger, and A. Edmonds, “Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil,” Fertility and Sterility2004; 82:S83–S84.
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2018-12-31
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How to Cite
1.
Mishra DA, Arya DP. Medical management of endometriosis. Int J of Pharmc Res [Internet]. 2018 Dec. 31 [cited 2025 Mar. 14];8(12):127-30. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/4993