Onset of action of aqueous extracts of Ceiba Pentandra and Pseudocedrela Kotschyi plants with potential antipyretic activity on young rats and their interactions with antimalaria drugs

Authors

  • Ayoman Thierry-Lenoir Djadji Laboratory Pharmacology, Clinical Pharmacy and Therapeutic: Laboratory of Pharmacology, UFR Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University
  • Donald Brou Koua Laboratory Pharmacology, Clinical Pharmacy and Therapeutic: Laboratory of Pharmacology, UFR Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University
  • Sandrine Any-Grah-Aka Sandrine Laboratory of Pharmacotechnic, Galenic Formulation and Pharmaceutical Legislation
  • Etienne Kouakou Effo Laboratory Pharmacology, Clinical Pharmacy and Therapeutic: Laboratory of Pharmacology, UFR Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University
  • Landry Sylvain Kouakou Laboratory Pharmacology, Clinical Pharmacy and Therapeutic: Laboratory of Pharmacology, UFR Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University
  • Genevieve Irie-N'guessan Laboratory Pharmacology, Clinical Pharmacy and Therapeutic: Laboratory of Pharmacology, UFR Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University
  • Gisele N'doua Kouakou-Siransy Laboratory Pharmacology, Clinical Pharmacy and Therapeutic: Laboratory of Pharmacology, UFR Pharmaceutical and Biological Sciences, Felix Houphouet-Boigny University

Keywords:

Acute toxicity, chemicals, herbal products

Abstract

Introduction: Several classical antipyretics are used to treat fever. But their harmful sides effects have led to the research of the others alternative based on medicine herbals. Rarely, studies are focused on the onset of action and assess effects of Drugs Herbal interaction in vivo using experimental models. The main objective of this work is to assess potential antipyretic activities of two African plants ( Ceiba P . and Pseudocedrela K. ) concerning the onset of action and evaluate the effects of their association to the combination based on artemisinin (CTA).

Materials and methods: Turpentine 2 mL/Kg, yeast Brewers 20%, Boiled Milk 1ml/kg were used to induce fever in the rats. The crudes of the extract of Ceiba P . 200mg/Kg; 400mg/Kg and Pseudocedrela K. 100 and 150 mg/Kg were administered orally and the temperatures (

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Published

2018-12-31

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Section

Research Articles

How to Cite

1.
Djadji AT-L, Koua DB, Sandrine SA-G-A, Effo EK, Kouakou LS, Irie-N'guessan G, et al. Onset of action of aqueous extracts of Ceiba Pentandra and Pseudocedrela Kotschyi plants with potential antipyretic activity on young rats and their interactions with antimalaria drugs. Int J of Pharmc Res [Internet]. 2018 Dec. 31 [cited 2025 Mar. 14];8(12):137-42. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/4957