Onset of action of aqueous extracts of Ceiba Pentandra and Pseudocedrela Kotschyi plants with potential antipyretic activity on young rats and their interactions with antimalaria drugs
Keywords:
Acute toxicity, chemicals, herbal productsAbstract
Introduction: Several classical antipyretics are used to treat fever. But their harmful sides effects have led to the research of the others alternative based on medicine herbals. Rarely, studies are focused on the onset of action and assess effects of Drugs Herbal interaction in vivo using experimental models. The main objective of this work is to assess potential antipyretic activities of two African plants ( Ceiba P . and Pseudocedrela K. ) concerning the onset of action and evaluate the effects of their association to the combination based on artemisinin (CTA).
Materials and methods: Turpentine 2 mL/Kg, yeast Brewers 20%, Boiled Milk 1ml/kg were used to induce fever in the rats. The crudes of the extract of Ceiba P . 200mg/Kg; 400mg/Kg and Pseudocedrela K. 100 and 150 mg/Kg were administered orally and the temperatures (
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