Cognition enhancement of Punicalagin following intracerebroventricular injection of Aβ (25-35) model of mice
Cognition enhancement of Punicalagin
Keywords:
Free radicals, Antioxidant, Bombax ceiba, lipid peroxidationAbstract
The hallmark in the pathology of Alzheimer disease is the deposition of amyloid plaques throughout the brain which lead to the deterioration of neuronal function and eventually they die. This damage spreads to hippocampus, region responsible for forming memories. This will ultimately lead to impairment in cognition. Punicalagin a polyphenolic compound found in pomegranate ( Punica granatu m) having proven antioxidant and anti-neuroinflammatory activities in many studies. In recent studies, it was evident that there is a link between Alzheimer disease and neuroinflammation. In the present study, intracerebroventricular injection of Aβ (25-35) was given to all the three groups of mice except the control group which received only bi- distilled water. Donepezil and Punicalagin at the dose of 10 and 600mg/kg were given to the standard and the test group respectively following icv injection of Aβ (25-35). The results revealed that Punicalagin (600mg/kg) showed significant improvement in cognition as compared to that of the control group.Downloads
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