EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF AGLAIA ELEAGNOIDEA (A. JUSS) BENTH STEM EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS

Authors

  • K. Manikya Kumari Add afffilation 19
  • V. Padmaja Professor, Department of Botany, Andhra University, Visakhapatnam-530003, AP,

DOI:

https://doi.org/10.7439/ijpr.v2i3.4216

Abstract

Objective: The present study was intended to evaluate the hepatoprotective activity of hydro alcoholic extract of stem of Aglaia eleagnoidea (A. Juss) Benth. It is a medicinal plant found in the dense and moist forests in Western and Eastern Ghats, and also in many drier parts of Indian states like Andhra Pradesh, Karnataka, Kerala, Bihar, Andaman and Nicobar Islands. Method: The hydro alcoholic extract and its hexane, ethyl acetate and methanol fractions of Aglaia eleagnoidea (A. Juss) Benth., at the doses of 150,300 and 600 mg/kg and two isolated phytoconstituents (50mg/kg) was administered orally by suspending in Sodium CMC to the Wister albino rats with carbon tetra chloride(1ml/kg) induced hepatotoxicity. Silymarin (50mg/kg) was given as reference standard drug. This dose dependant study was followed by histopathological studies of ccl4 and plant extract treated liver tissue. Result: Studies of blood samples of carbon tetra chloride treated rats showed significant increase in the levels of serum enzyme activities, reflecting the liver injury caused by paracetamol. It was evident from the results that after treatment with the plant extract, there was a significant reduction in the levels of serum biochemical parameters serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALKP) and total bilirubin (TBL) induced by carbon tetrchloride hepatotoxicity. The histopathological observations also showed that plant extract treated liver sections against carbon tetrchloride induced hepatotoxisity revealed the well preserved cellular architexture of the liver tissue. Conclusion: The present study indicates the potential hepatoprotective activity of Aglaia eleagnoidea stem and its bioactive phytoconstituents predominantly stigmasterol, ?-sitosterol, Daucosterol and unidentified polyphenols. These compounds probably by suppressing the activity of reactive oxygen species which cause cellular damage, there by offering protection to the targeted tissue against the hepatotoxicity induced by carbon tetra chloride in albino rats.

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Published

2012-09-29

Issue

Vol. 2 No. 3 (2012): Jul- Sep

Section

Research Articles

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How to Cite

1.
Kumari KM, Padmaja V. EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF AGLAIA ELEAGNOIDEA (A. JUSS) BENTH STEM EXTRACT AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS. Int J of Pharmc Res [Internet]. 2012 Sep. 29 [cited 2024 Oct. 18];2(3):117-24. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/4216