A study on the evaluation of anti-diarrhoeal efficacy of a polyherbal formulation versus loperamide in rat models

Authors

  • Santanu Munshi CNMC, Kolkata,WB
  • Ranjita Santra (Dhali) CSTM, Kolkata, WB
  • Tapas Sur IPGMER, Kolkata, WB
  • Manab Nandy MCH, Kolkata, WB
  • Swati Bhattacharya RGKMC, Kolkata, WB

DOI:

https://doi.org/10.7439/ijpr.v6i11.3729

Abstract

Objective: To assess the efficacy of a new polyherbal formulation LQ14 for acute diarrhea in rats and to explore its mechanism of action as an anti-diarrhoeal agent. Materials and methods: Wistar albino rats (average body weight 150g) were divided into five groups of six animals each. Group 1 control (2 ml/kg distilled water), group 2 received loperamide (3 mg/kg) served as standard and group 3, 4, and 5 received test drug LQ14 (1 ml/kg, 2 ml/kg and 4 ml/kg respectively) 1 hour before castor oil administration. All drugs were given by oral route. Diarrhea was induced by administering 1 ml of castor oil. Castor Oil-Induced Diarrhoea, Castor Oil-Induced Enteropooling and Small Intestinal Transit were the models used in this study. Results: LQ14 possess significant anti-diarrhoeal activity due to its effect on reduction of frequency of diarrhoea episodes, delay in gastrointestinal propulsion and inhibition of fluid accumulation in the intestinal tract of rats. Conclusion: The new polyherbal formulation was found to possess anti-diarrhoeal activity as it showed significant reduction of number of diarrhoea stools, delayed gastrointestinal propulsion and inhibition of fluid accumulation in the intestinal tract of rat

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Author Biographies

  • Santanu Munshi, CNMC, Kolkata,WB
    Pharmacology, Professor
  • Ranjita Santra (Dhali), CSTM, Kolkata, WB
    Clinical & Experimental Pharmacology, Assistant Professor
  • Tapas Sur, IPGMER, Kolkata, WB
    Pharmacology, Research Associate
  • Manab Nandy, MCH, Kolkata, WB
    Pharmacology, Associate Professor
  • Swati Bhattacharya, RGKMC, Kolkata, WB
    Pharmacology, Associate Professor

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Published

2016-12-01

Issue

Section

Research Articles

How to Cite

1.
Munshi S, Santra (Dhali) R, Sur T, Nandy M, Bhattacharya S. A study on the evaluation of anti-diarrhoeal efficacy of a polyherbal formulation versus loperamide in rat models. Int J of Pharmc Res [Internet]. 2016 Dec. 1 [cited 2025 Mar. 17];6(11):343-8. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/3729