Development and in vitro- in vivo evaluation of Nitazoxanide sustained release tablets
DOI:
https://doi.org/10.7439/ijpr.v6i2.3017Abstract
Objective: The objective of the present investigation was to develop a sustained release (SR) tablet formulation of Nitazoxanide. Methods: Nitazoxanide Tablets were prepared by employing wet granulation methods and hydrophilic polymers used as drug release retardants. The dissolution data also evaluated for the drug release mechanism and kinetics. The optimized formulation was subjected for in vivo studies in rabbits. Results: Based on data obtained from the in vitro drug release studies 5%w/w of Methocel K100M was selected as a release retardant. The drug release followed first order kinetics and fickian diffusion. Conclusion: Present investigation indicates that the developed formulation was able to sustain the drug release.Downloads
References
Jantzen GM, Robinson JR. Sustained and controlled drug delivery system. In: Banker G. Rhodes. Modern Pharmaceutics, 3rd ed, Marcel Dekker.1996.
Leon Shargel, Susanna Wu-Pong, Andrew BC Yu. Modified-release drug products. In: Applied Biopharmaceutics & Pharmacokinetics, 5th ed. 2004.
Mandana A, John C, Sunil JV, Paul MF, Russell PV, Amir R. Sustained release delivery of highly water-soluble compounds. US Patent, WO/2000/025757, 2000.
Maggi L, Bruni R, Conte U. High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms. Int J Pharm., 195(1-2):229-238, 2000.
Ebube NK, Hikal A, Wyandt CM, Beer DC, Miller LG, Jones AB. Sustained release of acetaminophen from heterogeneous matrix tablets, influence of polymer ratio, polymer loading and coactive on drug release. Pharm Dev Technol., 2:161-170, 1997.
Aulton ME, Wells TI. Pharmaceutics: The science of dosage form design. London, England: Churchill Livingstone; 1998.
Cooper J, Gunn C. Powder flow and compaction. In: Carter SJ, editor. Tutorial Pharmacy, New Delhi: CBS Publishers and Distributors, 1986
Jagadish B, Kanda P, Sivashanker R, Vijaykumar P, Yelchuri R, Reddy L, The development of dissolution method for nitazoxanide sustained release tablets, AAPS PharmSciTech. 2010.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- Author must Submit Copyright form After acceptance of Article
How to Cite
