Role of Hydroalcoholic and Aqueous leaf extracts of Murraya koenigii in Gastroprotection

Abstract

Murraya koenigii leaves are regularly used in our diet and hence, our gastrointestinal tract is regularly exposed to this extract. Therefore the present study was focused on the evaluation of the Gastroprotective action of Murraya koenigii leaf extracts on Pancreas and Duodenum. Male albino mice (35-40 gm) were treated with Murraya koenigii leaf extracts (Hydroalcoholic and Aqueous), against Carbon tetrachloride (CCl₄) induced toxic model for seven days, using two different dose concentrations. The mice were divided into six groups, including Group I Untreated Controls and Group I A Vehicle controls. The negative control (Group II) was administered CCl₄ along with vehicle (olive oil)_. Group III and IV were administered low dose (150 mg/kg body weight) of aqueous and hydroalcoholic extracts after inducing toxicity with CCl_4. Similarly_, Group V and VI were administered with high dose (250mg/kg body weight) of the extracts. Biochemical markers included ATPase, ALKpase, ACPase, SDH, Protein and Cholesterol in both target tissues; duodenal Triglycerides and Pancreatic amylase were also estimated. It was observed that Murraya koenigii leaf extracts had a mitigative effect and were able to bring the elevated levels of ATPase, SDH, ALKPase, ACPase and Amylase to near normal values. The hydroalcoholic extract proved to be more effective than the aqueous extract. Hence, Murraya koenigii leaf extracts have potent ameliorative action on the CCl4 induced toxicity in the duodenum and pancreas, manifesting potent gastroprotective activity. The present study has significant impact since the plant is used extensively in both cuisine and medication.