Effect of Gymnema sylvestre on the pharmacokinetics and pharmacodynamics of 0.5mg & 0.6mg Glibenclamide in diabetic rats

Authors

  • Shravan Kumar Dholi Research Scholar (PhD), Depatment of Pharmacology, JNTUK, Kakinada, A.P-533003
  • Ramakrishna Raparla Depatment of Pharmaceutics, Vaageswari Institute of Pharmaceutical Sciences, Beside LMD Police Station, Ramakrishna Colony, Karimnagar, A.P.-505481
  • Kannappan , Department of Pharmacy, Annamali University, Annamali Nagar, Tamil Nadu-608002

DOI:

https://doi.org/10.7439/ijpr.v5i8.2356

Keywords:

Imerslund Grasbeck syndrome, pancytopenia, Vitamin B12, proteinuria.

Abstract

Traditional medicines derived from medicinal plants are used by about 60 per cent world population. Diabetes is an important human ailment officiating many from various walk of life in different countries including India. It providing to a major health problem, especially in the rural and subrural areas. Gymnema sylvestre R.Br. (Asclepiadaceae) is a herb distributed throughout the world. The leaves of the plant are widely used for the treatment of diabetes and as diuretic in India proprietary medicine. Gymnema sylvestre an Ayurvedic herb, came to be known as destroyer of sugar because, in ancient times, Ayurvedia physicians observed that chewing a few leaves of G. sylvestre suppressed the taste of sugar. It is used totally all over India for controlling blood sugar. This study was to determine effect of Gymnema sylvestre on the pharmacokinetics and pharmacodynamics of Glibenclamide in streptozotocin induced diabetic rats . Results have indicated the negative effect of Gymnema Sylvestre on pharmacokinetics but positive effect on pharmacodynamics of Glibenclamide.

Downloads

Author Biography

  • Shravan Kumar Dholi, Research Scholar (PhD), Depatment of Pharmacology, JNTUK, Kakinada, A.P-533003
    PHARMACOLOGY

Downloads

Published

2015-08-30

Issue

Vol. 5 No. 8 (2015): Aug

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
    4. Author must Submit Copyright form  After acceptance of Article

How to Cite

1.
Dholi SK, Raparla R, , K. Effect of Gymnema sylvestre on the pharmacokinetics and pharmacodynamics of 0.5mg & 0.6mg Glibenclamide in diabetic rats. Int J of Pharmc Res [Internet]. 2015 Aug. 30 [cited 2025 Mar. 15];5(8):172-8. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/2356
Crossref
Scopus
Google Scholar
Europe PMC