Hepatoprotective activity of methanolic extract of Mussaenda philippica (stems) against anti-tubercular drugs induced hepatotoxicity
DOI:
https://doi.org/10.7439/ijpr.v4i4.135Keywords:
Mussaenda philippica, anti-tubercular drugs, Hepatoprotective activity, Methanolic extractAbstract
The present study was designed to evaluate the hepatoprotective effect of methanolic extract of Mussaenda philippica against isoniazid and rifampicin induced hepatotoxicity in experimental rats. Six groups of six rat were selected for the study. Methanolic extract of Mussaendaphilippica at a dose of 100, 200 and 400 mg/kg as well as silymarin (50 mg/kg) were administered orally once daily for 14 d in isoniazid and rifampicin group. The serum levels of glutamic oxaloacetic transaminase (SGOT), glutamate pyruvate transaminase (SGPT), alkaline phosphatase, and bilirubin were estimated along with total protein. Histopathological analysis was carried out to assess injury to the liver. The altered biochemical parameters were significantly reverting back by the methanolic extract treatment. Histopathology also supported the biochemical variation. From this study it has been concluded that the methanolic extract of Mussaendaphilippica shows significant hepatoprotective activity.
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