The Effect of Atorvastatin on lung function and sputum cell count in Chronic Asthma patients

Authors

  • Vandana Avinash Badar Associate professor,Department of Pharmacology ,IGGMC,Nagpur
  • Swapnil Narayan Deshmukh Resident doctor,Department of Pharmacology,IGGMC,Nagpur
  • Sanjay Navale Resident doctor,Department of Pharmacology,IGGMC,Nagpur
  • Radha Munje Professor and Head,Department of Chest and TB,IGGMC,Nagpur
  • Anjali Badar Lecturer,Department of Statistics,Babasaheb Ambedkar College,Nagpur

DOI:

https://doi.org/10.7439/ijpr.v4i4.125

Abstract

Background: Asthma is a chronic inflammatory disease with incomplete recovery. Atorvastatin has documented in vitro and vivo anti-inflammatory effect.So effect of atrovastatin in chronic asthma patient was studied in TB and chest department of Tertiary care hospital of central India. Objective : The effect of Atorvastatin on lung function and sputum cell count in chronic Asthma. Material and Methods: In randomized ,parallel ,double blind placebo controlled clinical trial 60 chronic asthma patients who were taking inhaled corticosteroids were to receive either Atrovastatin or placebo for 12 weeks. Pulmonary function test, sputum cell count and lipid profile were done. Result: With Atorvastatin significant improvement in ACQ(asthma control questionnaire), significant decrease in SCC(sputum cell count) and significant reduction in risk of asthma exacerbations after 12 weeks. No significant improvement in all parameters were seen with placebo.It was observed that mean changes in ACQ, SCC were statistically significant p 0.05 in Atorvastatin group as compared to placebo group, but mean changes in FEV1(pre) and FEV1(post),PEFR were not statistically significant at 12 weeks between the 2 groups. Conclusion: Atorvastatin significantly improved asthma control according to asthma control questionnaires and reduced risk of asthma exacerbations correlated with reduction in sputum cell count.

Downloads

Download data is not yet available.

Author Biography

  • Swapnil Narayan Deshmukh, Resident doctor,Department of Pharmacology,IGGMC,Nagpur
    Resident doctor,Department of Pharmacology,IGGMC,Nagpur

Downloads

Published

2014-11-30

Issue

Vol. 4 No. 4 (2014): Oct-Dec

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
    4. Author must Submit Copyright form  After acceptance of Article

How to Cite

1.
Badar VA, Deshmukh SN, Navale S, Munje R, Badar A. The Effect of Atorvastatin on lung function and sputum cell count in Chronic Asthma patients. Int J of Pharmc Res [Internet]. 2014 Nov. 30 [cited 2024 Dec. 4];4(4):194-8. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1481