Proton-Pump Inhibitors Therapy and Blood Pressure Control

Authors

  • Pedro Joya-Vazquez
  • M Asuncion Bacaicoa
  • Raul Velasco
  • Jose L. Chicon
  • Sara Trejo
  • M. Antonia Carrasco
  • N. Roberto Robles Nephrology. H. Infanta Cristina. Badajoz
  • Juan F. Sanchez Munoz-Torrero

DOI:

https://doi.org/10.7439/ijpr.v4i3.116

Keywords:

High risk pregnancy, Maternal and child health, MDG's, Maternal mortality

Abstract

Objective: To evaluate the potential impact of inhibitors of proton-pump in blood-pressure. . Methods : In a 24-hour-ambulatory-blood-pressure-monitoring (AMBP)-database we analyzed records of 462-hypertensive-patients according Proton-Pump Inhibitors (PPI). 150(33%)-patients were regularly users of PPI, and 312(67%) nonusers of PPI. Ambulatory-blood-pressure was measured non-invasively for 24--hours by the Spacelab-devices programmed-to-measure every 20-minutes during-daytime and every 60-minutes during-nighttime. Results : Systolic-blood-pressure(SBP) was lower in the Proton-Pump-Inhibitors (PPI)-group (13520.vs.13916mmHg, p=0,02) as well as diastolic-blood-pressure (DBP) (7610.vs.8310mmHg, p 0.001). Multivariate-analysis showed that use of beta-blocker(OR, 2.60) and PPI(OR, 2.70), were independently associated with blood-pressure-control. Conclusions : This study shows that concomitant PPI therapy in hypertensive-patients was associated with a small but statistically significant-reduction in 24-hours-BP, even after multivariate-adjustment. However, This statistical difference seems to lack clinical relevance.

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Published

2014-09-30

Issue

Vol. 4 No. 3 (2014): Jul-Sep

Section

Research Articles

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How to Cite

1.
Joya-Vazquez P, Bacaicoa MA, Velasco R, Chicon JL, Trejo S, Carrasco MA, et al. Proton-Pump Inhibitors Therapy and Blood Pressure Control. Int J of Pharmc Res [Internet]. 2014 Sep. 30 [cited 2025 Mar. 14];4(3):142-7. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1270
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