Ornithine aspartate attenuates thioacetamide induced hepatic encephalopathy through GABA-benzodiazepine receptors

Authors

  • Abul Kalam Najmi Department of Pharmacology, Faculty of Pharmacy Hamdard University New Delhi 110 062
  • K. K. Pillai Department of Pharmacology, Faculty of Pharmacy Hamdard University New Delhi 110 062
  • S. N. Pal World Health Organization 20, Avenue Appia CH-1211 Geneva 27
  • Aftab Ahmad Health Information Technology Department Jeddah Community College King Abdul Aziz University Jeddah-21589
  • A. S. Nazmi Department of Pharmacy Oman Medical College Muscat
  • Mohd. Akhtar Department of Pharmacology, Faculty of Pharmacy Hamdard University New Delhi 110 062

DOI:

https://doi.org/10.7439/ijpr.v4i3.92

Abstract

The aim for this study was to investigate the effect of L-ornithine-L-aspartate (OA) in combination with benzodiazepine agonist (diazepam) and antagonist (flumazenil) in thioacetamide (TAA) induced hepatic encephalopathy (HE) in mice. HE was induced in mice by administration of TAA (25mg/kg, i.p.) thrice at 24 hours interval. OA (2gm/kg, p.o.), diazepam (4mg/kg, i.p.) and flumazenil (5mg/kg, i.p.) were administered in different combinations along with TAA and the mice were observed for motor activity, grip strength, traction test and mortality. TAA administration produced stage II III of HE in mice with highly significant reduction in motor activity. OA protected the animals significantly in TAA and TAA plus diazepam treated groups as was done by flumazenil. Taken together, the findings of the present study suggest that OA actions in TAA induced HE in mice may be mediated through GABA-benzodiazepine receptors.

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Published

2014-09-30

Issue

Vol. 4 No. 3 (2014): Jul-Sep

Section

Research Articles

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How to Cite

1.
Najmi AK, Pillai KK, Pal SN, Ahmad A, Nazmi AS, Akhtar M. Ornithine aspartate attenuates thioacetamide induced hepatic encephalopathy through GABA-benzodiazepine receptors. Int J of Pharmc Res [Internet]. 2014 Sep. 30 [cited 2025 Mar. 14];4(3):134-7. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1268
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