Antidiabetic activity of Randia dumetorum against streptozotocin (STZ) induced diabetics in rats

Authors

  • G. Viji Stella Bai Department of Botany, Kundavai Naachiyaar Government Arts College For Women (Autonomous), Thanjavur, Tamil Nadu
  • S. Gandhimathi Research Scholar, Department of Botany, Kundavai Naachiyaar Government Arts College For Women (Autonomous), Thanjavur, Tamil Nadu

DOI:

https://doi.org/10.7439/ijpr.v4i3.103

Abstract

In the present investigates the antidiabetic activity of Randia dumetorum against streptozotocin (stz) induced diabetics in rats. The rats treated with Streptozotocin showed a significant increased in glucose level and altered level of lipid profile, heamoglobin and insulin were observed. The mechanism underlying STZ hyperglycemia in diabetes mellitus involves over-production (excessive hepatic glycogenolysis and gluconeogenesis) and decreased utilization of glucose by the tissues. Fifteen days administration of ethanolic extract of leaf of the Randia dumetorum (500mg/kg b.wt.) and standard as glibenclamide (0.25mg/kg ) to diabetic rats resulted in significant reduction in blood glucose level, restored heamoglobin, and lipid profile as compared to diabetic rats. The present study suggests that the Randia dumetorum leaves extracts had synergetic hypoglycemic and hypolipidemic effect revealed by decreased glucose, lipid levels and heamoglobin therefore attribute to therapeutic value of the Randia dumetorum extracts of leaves to combat the diabetic condition in rats. The effect of Randia dumetorum leaves was better than glibenclamide. The potential activity of Randia dumetorum leaves may due to the presence of phytochemicals.

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Published

2014-09-30

Issue

Vol. 4 No. 3 (2014): Jul-Sep

Section

Research Articles

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How to Cite

1.
Stella Bai GV, Gandhimathi S. Antidiabetic activity of Randia dumetorum against streptozotocin (STZ) induced diabetics in rats. Int J of Pharmc Res [Internet]. 2014 Sep. 30 [cited 2025 Mar. 14];4(3):126-9. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1266
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