Role of Neprilysin in Various Diseases

Authors

  • Gayathiri K. Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry 605 006
  • Prabhavathi A. Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry 605 006
  • Tamilarasi R. Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry 605 006
  • Vimalavathini Ramesh Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry 605 006
  • S. Kavimani Department of Pharmacology, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, Pondicherry 605 006

DOI:

https://doi.org/10.7439/ijpr.v4i3.115

Abstract

Neprilysin is a membrane bound zinc metallo-protease enzyme which catalyses a number of endogenous peptides. Hence exploring the physiological and biological role of these NEP family enzymes may provide novel approaches for treatment of major diseases. Neprilysin inhibitors have shown promising results for treatment of hypertension, heart failure, renal failure, hyperplasia, analgesia and improvement of ?-cell function in obese type 2 diabetes mellitus. However decrease in neprilysin levels may lead to neurogenic inflammatory condition and also contributes to prostate cancer. Hence neprilysin being widely distributed in the body it is crucial to maintain the cellular levels of neprilysin since its up or down regulation may lead to cardiovascular diseases, cancer and dementia.

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Published

2014-09-30

Issue

Vol. 4 No. 3 (2014): Jul-Sep

Section

Review Article

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How to Cite

1.
K. G, A. P, R. T, Ramesh V, Kavimani S. Role of Neprilysin in Various Diseases. Int J of Pharmc Res [Internet]. 2014 Sep. 30 [cited 2025 Mar. 14];4(3):91-4. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1259
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