Ethanolic Root Extract of Jatropha curcas L. relieves Hyperalgesia in Arthritis Model in Rats.

Authors

  • Kukuia Kennedy Kwami Edem Department of Pharmacology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra
  • Boampong Johnson Nyarko Department of Biomedical and Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast
  • Kyei Samuel Department of Optometry, Faculty of Physical Science, University of Cape Coast, Cape Coast
  • Annane Rex Frimpong Department of Biomedical and Forensic Sciences, School of Biological Sciences, University of Cape Coast, Cape Coast
  • Obese Ernest Department of Pharmacology, University of Cape Coast Medical School, Cape Coast,

DOI:

https://doi.org/10.7439/ijpr.v4i1.64

Abstract

This work evaluated the analgesic property of ethanolic extract of Jatropha curcas in arthritic/skeletal pain models. Acute skeletal hyperalgesia was induced in knee joints of rats with 3% carrageenan-kaolin mixture. Twelve hours later, the rats were grouped and treated orally with 30, 100 and 300 mg/kg Jatropha curcas or morphine (1, 3 and 10 mg/kg). Pain thresholds were measured by knee compression in the ipsilateral limb. In a separate experiment to determine the effect of ethanolic root extract of Jatropha curcas (30-300 mg/kg, p.o. ) and morphine (1-3 mg/kg, p.o. ) on chronic skeletal hyperalgesia, the extracts and morphine treatments were administered 2 weeks after the induction of the pain with 3% carrageenan-kaolin mixture. The effects of Jatropha curcas on chronic skeletal hyperalgesia in both the ipsilateral and contralateral paws was assessed in the Randall-Selitto test. Jatropha curcas (P 0.05) and morphine (P 0.05) significantly reduced acute knee hyperalgesia in the ipsilateral limb. Chronic skeletal hyperalgesia was dose-dependently inhibited by the extract of J. curcas and the standard drug morphine in the ipsilateral and contralateral paws. Ethanolic root extract of Jatropha curcas relieves skeletal pain in rats.

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Published

2014-03-30

Issue

Vol. 4 No. 1 (2014): Jan- Mar

Section

Research Articles

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How to Cite

1.
Edem KKK, Nyarko BJ, Samuel K, Frimpong AR, Ernest O. Ethanolic Root Extract of Jatropha curcas L. relieves Hyperalgesia in Arthritis Model in Rats. Int J of Pharmc Res [Internet]. 2014 Mar. 30 [cited 2025 Mar. 14];4(1):18-21. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1246
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