Investigation of poly-herbal aqueous extract for potential anti-ulcer activity

Authors

  • Deepak S. K. Bharat Institute of Technology, Hyderabad
  • G.R.Sreenivas Reddy Bharat Institute of Technology, Hyderabad
  • Md. Mohiuddin Sree Datta Institute of Pharmacy, Hyderabad
  • Pranav Kumar A.V.R Bharat Institute of Technology, Hyderabad
  • D.M. Sai Krishna Bharat Institute of Technology, Hyderabad
  • M. S. Potbhare NNR School of Pharmacy, Hyderabad

DOI:

https://doi.org/10.7439/ijpr.v3i3.57

Keywords:

Metagenomics, Microorganism, Computational Methods, bioinformatics

Abstract

The aqueous polyherbal extract of betel, clove, fennel and black catechu was evaluated for gastro-protective (antiulcer) activity in rats using the aspirin and ethanol induced ulcer models. Efficacy was assessed by determination of ulcer index and percentage of ulcer protection. Antioxidant activity of extract was evaluated by DPPH free radical scavenging procedure. Oral administration of the aqueous extract (250 mg/kg) and (500 mg/kg) showed dose dependent antiulcer activity and protected gastric lesions by about 65 to 75% respectively compared to standard drug Omeprazole (98%). The findings suggest that the polyherbal extract have significant gastro-protective activity.

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Published

2013-09-30

Issue

Vol. 3 No. 3 (2013): Jul- Sep

Section

Research Articles

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How to Cite

1.
K. DS, Reddy G, Mohiuddin M, A.V.R PK, Sai Krishna D, Potbhare MS. Investigation of poly-herbal aqueous extract for potential anti-ulcer activity. Int J of Pharmc Res [Internet]. 2013 Sep. 30 [cited 2025 Mar. 14];3(3):53-8. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1238
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