HPTLC analysis and Anti-inflammatory activity of Jatropha gossypifolia L. root in mice and Wistar rats

Authors

  • Rani B Bhagat PDEA'S Anantrao Pawar College, Pirangut Tal Mulshi Dist Pune pin 412115 Maharashra India

DOI:

https://doi.org/10.7439/ijpr.v3i1.36

Abstract

Jatropha gossypifolia has been used in Indian traditional system but there is paucity of scientific data on anti-inflammatory activity of root. Anti-inflammatory activity was evaluated by TPA (12-O-tetradecanoylphorbol-13-acetate) induced ear inflammation, carrageenan-induced paw edema and cotton pellet granuloma. Topical application of 0.5 and 1 mg extract significantly reduced the TPA induced ear inflammation. The extract (125 mg/kg p.o) significantly reduced the carrageenan induced edema. Seven days administration of 50 and 100 mg/kg of extract significantly reduced the cotton pellet granuloma. The activity might be due to effects on several mediators involving cyclooxygenase pathway resulting in prostaglandin formation and leukocyte migration.

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Published

2013-04-01

Issue

Vol. 3 No. 1 (2013): Jan-Mar

Section

Research Articles

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How to Cite

1.
Bhagat RB. HPTLC analysis and Anti-inflammatory activity of Jatropha gossypifolia L. root in mice and Wistar rats. Int J of Pharmc Res [Internet]. 2013 Apr. 1 [cited 2025 Mar. 14];3(1):13-7. Available from: https://ssjournals.co.in/index.php/ijpr/article/view/1231
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