Synthesis and antimicrobial evaluation of thiazole derivative

Authors

  • Vijayshri Rokde Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra,
  • Mayuri Hadge Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra,
  • Dhiraj Dhonge Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra,
  • Ujwala Mahajan Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra,

Keywords:

Antimicrobial/antibacterial activity, Thiazole derivatives

Abstract

Substituted heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly useful as therapeutic agents. The toxicity, side effects, and resistance of common pathogens to standard drugs play important roles in treatment failure. Therefore, searching for new antimicrobial agents with specific activity, possibly acting through mechanism new compound carrying nitro group was synthesized. Newly synthesized compound was characterised by evaluation test and thin layer chromatography (TLC). The extracts were tested for their antimicrobial activity against several gram-positive and gram-negative bacteria using agar diffusion method. Antibacterial activity was demonstrated especially against Gram-positive bacteria including multiresistant Staphylococcus strains. 

Downloads

Downloads

Published

2020-05-30

Issue

Vol. 10 No. 5 (2020)

Section

Research Articles

License

Copyright (c) 2020 International Journal of Pharmaceutical Chemistry

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
  • The author must submit Copyright form After acceptance of the article.

How to Cite

1.
Synthesis and antimicrobial evaluation of thiazole derivative. Int J of Pharm Chem [Internet]. 2020 May 30 [cited 2025 Jun. 10];10(5):e5526. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/5526