Synthesis and antimicrobial evaluation of thiazole derivative

Authors

  • Vijayshri Rokde Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra,
  • Mayuri Hadge Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra,
  • Dhiraj Dhonge Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra,
  • Ujwala Mahajan Department of Pharmaceutical Chemistry, Dadasaheb Balpande College of Pharmacy, Nagpur 440037, Maharashtra,

Keywords:

Antimicrobial/antibacterial activity, Thiazole derivatives

Abstract

Substituted heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly useful as therapeutic agents. The toxicity, side effects, and resistance of common pathogens to standard drugs play important roles in treatment failure. Therefore, searching for new antimicrobial agents with specific activity, possibly acting through mechanism new compound carrying nitro group was synthesized. Newly synthesized compound was characterised by evaluation test and thin layer chromatography (TLC). The extracts were tested for their antimicrobial activity against several gram-positive and gram-negative bacteria using agar diffusion method. Antibacterial activity was demonstrated especially against Gram-positive bacteria including multiresistant Staphylococcus strains. 

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Published

2020-05-30

Issue

Vol. 10 No. 5 (2020)

Section

Research Articles

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Copyright (c) 2020 International Journal of Pharmaceutical Chemistry

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How to Cite

1.
Synthesis and antimicrobial evaluation of thiazole derivative. Int J of Pharm Chem [Internet]. 2020 May 30 [cited 2025 Jun. 23];10(5):e5526. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/5526