Synthesis and antimicrobial activity of some new oxadiazole derivatives
DOI:
https://doi.org/10.7439/ijpc.v10i1.5364Keywords:
Oxadiazole, Oxadiazole, Dihydropyrimidine, Dihydropyrimidine, Antibacterial activity, Antibacterial activityAbstract
The series of novel 1,3,4-oxadiazoles were synthesized from ethyl 6-methyl-2-oxo-4-phenyl-1, 2, 3, 4-tetrahydropyrimidin-5- carboxylate. Synthesized compounds were characterized by IR, 1H NMR, and Mass spectral analysis and all the compounds are evaluated for their antimicrobial activities against different Gm (+ve) and Gm (-ve) bacterias. All the synthesized compounds has exhibited good antimicrobial activity against Gm (+ve) and Gm (-ve ) bacterias like Bacillus subtilis, Staphylococcus aureus and E.coli, Klebsiella pneumonia at higher concentration (100
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