Study of associative solvation of isoniazid with bovine serum albumin and glycine in aqueous medium through volumetric and acoustic analysis

Authors

  • Ashok Kumar Sahoo Department of Chemistry, Christ College, Cuttack
  • Sunil Kumar Pradhan Department of Chemistry, Brahmani College, Kendrapada
  • Ajay Kumar Patnaik Department of Chemistry, Ravenshaw University, Cuttack
  • Smrutiprava Das Ravenshaw University

DOI:

https://doi.org/10.7439/ijpc.v9i4.5310

Keywords:

Isoniazid, Isoniazid, Glycine, Glycine, Bovine Serum Albumin, Bovine Serum Albumin, Ultrasonic Velocity, Ultrasonic Velocity, Adiabatic compressibility, Adiabatic compressibility, apparent molal volume, apparent molal volume, Intermolecular free length, Intermolecular free length, Relative association, Relative association

Abstract

Measurements of Density (?), speed of sound (u), and viscosity (?) of a pharmacologically significant anti-tuberculosis drug isoniazid with a simplest amino acid Glycine and a poly aminoacid Bovine serum albumin (BSA) has been carried out in aqueous medium at normal body temperature of 370C and atmospheric pressure. An Aston par Densimeter, Ostwald viscometer, ultrasonic interferometer are used in the concentration range (2 x 10-4 to 2 x 10-3M) at 310K. The experimental data has been meticulously used to enumerate various parameters which assist to predict valuable information regarding the presence of different kinds of intermolecular interactions possible in both the ternary systems. The results lead to comparative study of associative parameters of (isoniazid + water + Glycine) vs (isoniazid + water + BSA) systems. The experimental outcomes were also interpreted in terms of various volumetric & acoustic parameters such as adiabatic compressibility (?s), intermolecular free length (Lf), apparent molal volume (?v),apparent molal compressibility (??), specific acoustic impedance (Z), relative association (RA) etc to establish solute-solvent and solute-solute interactions. The UV

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Published

2019-04-30

Issue

Vol. 9 No. 4 (2019)

Section

Research Articles

License

Copyright (c) 2019 International Journal of Pharmaceutical Chemistry

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How to Cite

1.
Study of associative solvation of isoniazid with bovine serum albumin and glycine in aqueous medium through volumetric and acoustic analysis. Int J of Pharm Chem [Internet]. 2019 Apr. 30 [cited 2026 Jan. 3];9(4):e5310. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/5310
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