Synthesis of 3-amino-2-(2-chlorophenyl)quinazolin-4(3H)-one by Conventional heating and Microwave Irradiation

Authors

  • Luthfi Ahmad Muchlashi Universitas Airlangga
  • Tutuk Budiati
  • Hadi Poerwono

Abstract

This study aims to compare conventional heating and microwave irradiation methods on the synthesis 3-amino-2-(2-chlorophenyl)quinazolin-4(3H)-one. For the compound to be completely synthesized which needed to carry out much heating for a long period of time. The reaction using conventional heating was required for 10 hours, whereas it takes only 5 minutes was conducted under 800 W microwave irradiation. The result showed that using microwave irradiation method significantly provided higher yield percentage (87%), compared to conventional heating (79%). This is considerably due to the mechanism transfer energy of both methods. Identification using FT-IR spectrophotometry and 1H-NMR spectrometry profile confirmed that the product for both methods was 3-amino-2-(2-chlorophenyl)quinazolin-4(3H)-one.

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References

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Published

2018-05-31

Issue

Vol. 8 No. 5 (2018)

Section

Short Communication

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How to Cite

1.
Synthesis of 3-amino-2-(2-chlorophenyl)quinazolin-4(3H)-one by Conventional heating and Microwave Irradiation. Int J of Pharm Chem [Internet]. 2018 May 31 [cited 2026 Jan. 3];8(5):31-3. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/4818