Designed Synthesis and Antimicrobial Studies of Novel Substituted Rhodanine Derivatives

Authors

  • Cici Mathew College of Pharmaceutical Sciences, Government Medical College, Trivandrum-695011
  • Bindu Saraswati Corporate Research & Development Centre, HLL Lifecare Limited, Akkulam,Trivandrum-695017
  • Nand Lal Corporate Research & Development Centre, HLL Lifecare Limited, Akkulam,Trivandrum-695017
  • Joyamma Varkey College of Pharmaceutical Sciences, Government Medical College, Alappuzha

Abstract

New rhodanine derivatives were prepared from substituted primary amines as antimicrobial agents. All the synthesized compounds ((IIa IIh )) were screened for antimicrobial activity using the micro dilution method recommended by the National Committee for Clinical Laboratory Standards, USA (CLSI 2006) to assess their antimicrobial activity. All the compounds were evaluated against gram positive bacteria: Bacillus subtilis MTCC 2756, Staphylococcus aureus MTCC 902; Gram negative bacteria: Escherichia coli MTCC 2622, Pseudomonas aeruginosa MTCC 2642, and Klebsiellapneumoniae MTCC 109. Fungal cultures used in the study were Aspergillusniger MTCC 282, Candida albicans MTCC 277, Candida tropicalis MTCC 230, Candida glabrata MTCC 3019 and Candida parapsilosis MTCC 6510.Allthe compounds exhibited potent anticandida activity against Candida albicans MTCC 277in the concentration range 2-16

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Published

2018-05-03

Issue

Vol. 8 No. 4 (2018): Apr

Section

Research Articles

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How to Cite

1.
Designed Synthesis and Antimicrobial Studies of Novel Substituted Rhodanine Derivatives. Int J of Pharm Chem [Internet]. 2018 May 3 [cited 2025 May 28];8(4):25-30. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/4813