Synthesis of New Barbiturate Esters derivatives as Intravenous Anesthetics: A new Dimension of Anesthesia Route: part-II*

Abstract

Conventional 1-methyl-2-oxobarbiturates and 1-methyl-2-thiobarbituates which are employed as anesthetics tend to accumulate in the body due to their slow rate of metabolism. As a result, the use of these compounds is restricted to either as an induction agent for anesthesia, subsequently maintained by volatile anesthetics or to a short surgical procedures only. In order to overcome the limitations of application of barbiturates as general anesthetics, avoiding the use of volatile agents, an attempt was made to the structural modifications of barbiturates molecules as intravenous anesthetics. In view of this contexts, it was conceived that, by incorporating metabolically labile ester functions in one or both of the side chain of barbiturates ring system, it could be achieved. Since this procedure could diminish the likelihood of barbiturates to be accumulated in the body, it might be possible to get safer barbiturate intravenous anesthetics.