synthesis and characterization of 2-methoxy-6-phenyl-5h-pyrrolo[3,4-b]pyrazine-5,7(6h)-dione and 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-one and some derivatives

Authors

  • Keerti Saraswat Department of Chemistry, Pratap University, Jaipur,
  • Shashi Kant Pandey Department of Basic Sciences & Humanities, Pratap University, Jaipur- 303002

DOI:

https://doi.org/10.7439/ijpc.v7i8.4267

Abstract

The process of producing a series of chemical combinations of 2-methoxy-6-phenyl-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione descendant [103-110] and 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine-5-one descendant [111-119], magnetized significant regard in prospective of curative requisition. The fusion was conved by conducting 2-hydroxyfuro [3,4-b]pyrazine-5,7-dione with equimolar Bromomethane in dry toluene at 0-5C to get combination 2-methoxyfuro[3,4- b ]pyrazine-5,7-dione which further at reflux condense with aniline derivatives to 2-methoxy-6-phenyl-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione derivatives with Potassium borohydride granules in methanol at 0-20C converted to 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine-5-one descendant. The distinctive nature of all the incorporated combinations have been described by manipulating basic inspection (elemental analysis), IR, 1 H NMR, 13 C NMR spectroscopical.

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Author Biography

  • Shashi Kant Pandey, Department of Basic Sciences & Humanities, Pratap University, Jaipur- 303002
    Chemistry

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Published

2017-08-30

Issue

Section

Research Articles

How to Cite

1.
synthesis and characterization of 2-methoxy-6-phenyl-5h-pyrrolo[3,4-b]pyrazine-5,7(6h)-dione and 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-one and some derivatives. Int J of Pharm Chem [Internet]. 2017 Aug. 30 [cited 2025 Jun. 20];7(8):121-30. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/4267