synthesis and characterization of 2-methoxy-6-phenyl-5h-pyrrolo[3,4-b]pyrazine-5,7(6h)-dione and 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-one and some derivatives

Abstract

The process of producing a series of chemical combinations of 2-methoxy-6-phenyl-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione descendant [103-110] and 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine-5-one descendant [111-119], magnetized significant regard in prospective of curative requisition. The fusion was conved by conducting 2-hydroxyfuro [3,4-b]pyrazine-5,7-dione with equimolar Bromomethane in dry toluene at 0-5C to get combination 2-methoxyfuro[3,4- b ]pyrazine-5,7-dione which further at reflux condense with aniline derivatives to 2-methoxy-6-phenyl-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione derivatives with Potassium borohydride granules in methanol at 0-20C converted to 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine-5-one descendant. The distinctive nature of all the incorporated combinations have been described by manipulating basic inspection (elemental analysis), IR, ¹ H NMR, ¹³ C NMR spectroscopical.