Synthesis And Biological Evaluation of Some New Schiff base 1,2,4-Triazole Derivatives

Authors

  • Sabiya Praveen Department of Pharmaceutical Chemistry, S. D. College of Pharmacy and Vocational Studies, Bhopa Road Muzaffarnagar 251001
  • Arvind Kumar Department of Pharmaceutical Chemistry, S. D. College of Pharmacy and Vocational Studies, Bhopa Road Muzaffarnagar 251001
  • Baby Rabiya Parveen Department of Pharmaceutical Chemistry, S. D. College of Pharmacy and Vocational Studies, Bhopa Road Muzaffarnagar 251001
  • Sonu . Department of Pharmaceutical Chemistry, S. D. College of Pharmacy and Vocational Studies, Bhopa Road Muzaffarnagar 251001
  • Himanshu Pal Department of Pharmaceutical Chemistry, S. D. College of Pharmacy and Vocational Studies, Bhopa Road Muzaffarnagar 251001

DOI:

https://doi.org/10.7439/ijpc.v7i6.4213

Keywords:

Vertebral artery, subclavianartery, arch of aorta

Abstract

A series of substituted 1,2,4-Triazole derivatives were synthesized, and their anticonvulsant activity and antimicrobial activity were evaluated which include the MES model and by Cup-plate method. However, further studies need to be carried out to ascertain the precise mechanism of action of anticonvulsant activity of these molecules. The compounds 4-[1-(2-Bromo-phenyl)-ethylideneamino]-5-pyridin-3-yl-2,4-dihydro[1, 2, 4] triazole-3-thione (SB-1) and 4-[1-(4-Fluoro-phenyl)-ethylideneamino]-5-pyridin-3-yl-2,4-dihydro[1, 2, 4] triazole-3-thione (SB-2) showed significant anticonvulsant activity and antibacterial activity against Escherichia coli.

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Published

2017-06-28

Issue

Vol. 7 No. 6 (2017): Jun

Section

Research Articles

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How to Cite

1.
Synthesis And Biological Evaluation of Some New Schiff base 1,2,4-Triazole Derivatives. Int J of Pharm Chem [Internet]. 2017 Jun. 28 [cited 2026 Jan. 3];7(6):95-9. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/4213
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