Synthesis and biological Evaluation of some new Amide Derivatives of Sulphonamide

Abstract

A series of substituted amide derivatives of Sulphonamides were synthesized, and their anticonvulsant activity and antimicrobial activity were evaluated which include the MES model and by Cup-plate method. However, further studies need to be carried out to ascertain the precise mechanism of action of anticonvulsant activity of these molecules. The compounds.N-(4-Acetylsulfamoyl-phenyl)-4-(4-chloro-3-methyl-phenyl)-4-oxo-butyramide (HP-1) showed significant anticonvulsant activity. Some compounds show the good antibacterial activity against Escherichia coli. The Compound 4-(4-chloro-3-methyl-phenyl)-4-oxo-N-(4-sulfamoyl-phenyl)-butyramide (HP-2) and 4-(4-Methoxy-phenyl)-4-oxo-N-(4-Sulfomoyl-Phenyl-)butyramide(HP-3) showed significant inhibitory characteristics with stronger antimicrobial activity against MTCC-521 gram(-)ve bacteria.