Evaluation of Anticancer, Antioxidant and Possible Anti-microbial Properties of extracts of Momordica diocia roots

Authors

  • Vijay Kumar G. Department of Pharmaceutical Chemistry, Jangaon institute of Pharmaceutical Sciences, Warangal, Telangana, India-506167
  • A. Rajasekhar Reddy Department of Pharmacy, K L University, Vaddeswaram, Guntur, A. P.522502
  • Vijaya Kumar B. Department of Pharmaceutical Chemistry, Jangaon institute of Pharmaceutical Sciences, Warangal, Telangana 506167

DOI:

https://doi.org/10.7439/ijpc.v7i5.4174

Abstract

Since many years, plants were known to possess anticancer activities against different cancer cell lines. In this paper, we report a study based on anticancer,anti-bacterial and antioxidant properties plants Momordicadioica . The roots of plant material were collected, shade dried and extracted with methanol using soxhlet extraction procedure. Anticancer activities were assayed with standard XTT colorimetric procedure against MCF-7 and Hep-G2 cell lines. From the analysis, it was found that Momordicadioica showed good cytotoxic activity on MCF-7 cell line at tested dose. Further work is in progress to evaluate the chemical constituents present in these plants

Downloads

Download data is not yet available.

References

Dubey NK, Kumar R, Tirupathi P. Global promotion of herbal medicine: India opportunity. Curr Sci 2004; 86(1): 37-41.

Sofowora A. Medicinal plants and traditional medicine. In: Africa. New York: John Willey Sons Ltd.; 1982, p. 6

Maharudra S Rakh, Amol N Khedkar, Nilesh N Aghav, Sanjay R Chaudhari, Antiallergic and analgesic activity of MomordicadioicaRoxb. Wild fruit seed, Asian Pacific Journal of Tropical Biomedicine, 2012, S192-S196

P Srinivas, S Ram Reddy, Screening for antibacterial principle and activity of Aervajavanica (Burm f) Juss. ex Schult. Asian Pacific Journal of Tropical Biomedicine, 2012, S838-S845

Namdeo A. Plant cell elicitation for production of secondary metabolites: A review. Pharmacog Rev 2007; 1: 69-79.

http://www.theplantlist.org/browse/A/Cucurbitaceae/Momordica/

Species in GRIN for genus Momordica; https://npgsweb.ars-grin.gov/gringlobal/taxonomylist.aspx?category=species&type=genus&value=a%20genus&id=7719

The International Plant Names Index; http://www.ipni.org/ipni/ advPlantNameSearch.do?find_family=&find_genus=Momordica&find_species=&find_infrafamily=&find_infragenus=&find_infraspecies=&find_authorAbbrev=&find_includePublicationAuthors=on&find_includePublicationAuthors=off&find_includeBasionymAuthors=on&find_includeBasionymAuthors=off&find_publicationTitle=&find_isAPNIRecord=on&find_isAPNIRecord=false&find_isGCIRecord=on&find_isGCIRecord=false&find_isIKRecord=on&find_isIKRecord=false&find_rankToReturn=spec&output_format=normal&find_sortByFamily=on&find_sortByFamily=off&query_type=by_query&back_page=plantsearch

Maharudra S Rakh, Amol N Khedkar, Nilesh N Aghav, Sanjay R Chaudhari, Antiallergic and analgesic activity of MomordicadioicaRoxb. Willd fruit seed, Asian Pacific Journal of Tropical Biomedicine,2012, S192-S196.

C. S. Shreedhara, V. P. Vaidya,

C. S. Shreedhara, H. N. Aswatha Ram, S. B. Zanwar, and F. P. Gajera,

B. Shrinivas, S. Anil, M. Parera, and M. Saxena,

A.Jain,M.Soni,L.Debetal,

K. Ilango, G. Maharajan, and S. Narasimhan,

V. P. Vaidya, C. S. Shreedhara,

M. S. Rakh and S. R. Chaudhari,

A. Jain and A. K. Singhai,

A. Jain and A. K. Singhai,

R. Gupta, P. Katariya, M. Mathur et al.,

M. S. Rakh and S. R. Chaudhari,

M. S. Rakh, A. N. Khedkar, N. N. Aghav, and S. R. Chaudhari,

P. P. Gupta, R. C. Srimal, and J. S. Tandon,

B. M. R. Fernandopulle, W. D. Ratnasooriya, and E. H.Karunanayake,

M. Vijayakumar, M. B. Eswaran, S. K. Ojha, C. V. Rao, andA. K. S. Rawat,

J. A. Arekar, A. R. Arekar, and G. T. Paratkar,

R. Singh, S. Hussain, R. Verma, and P. Sharma,

B. M. R. Fernandopulle, E. H. Karunanayake, and W. D.Ratnasooriya,

G. T. Reddy, B. R. Kumar, and G. K. Mohan,

R. Singh, A. Seherawat, and P. Sharma,

R. Sharma and V. Arya,

Martin Muthee Gakuubi,1,2 John M. Wagacha,1 Saifuddin F. Dossaji,1 and Wycliffe Wanzala3, Chemical Composition and Antibacterial Activity of Essential Oils of Tagetesminuta(Asteraceae) against Selected Plant Pathogenic Bacteria, International Journal of Microbiology, Volume 2016 (2016), Article ID 7352509

Ebrahimzadeh MA1, Bahramian F. Antioxidant activity of Crataeguspentaegynasubsp. elburensis fruits extracts used in traditional medicine in Iran. Pak J Biol Sci. 2009 Mar 1;12(5):413-9.

Mahmoudi, M, Ebrahimzadeh, M. A, Ansaroudi, F, Nabavi, S. Fand Nabavi, S. MAntidepressant and antioxidant activities of Artemisiaabsinthium L. at flowering stage, African Journal of Biotechnology Vol. 8 (24), pp. 7170-7175, 15 December, 2009.

Munari CC, de Oliveira PF, Campos JC, Martins Sde P, Da Costa JC, Bastos JK, Tavares DC, Antiproliferative activity of Solanum lycocarpumalkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines. J Nat Med. 2014 Jan;68(1):236-41.

Sunil Sagar, Luke Esau, BasemMoosa, Niveen M. Khasha, Vladimir B. Bajic, and Mandeep Kaur, Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells, Anticancer Agents Med Chem. 2014 Jan; 14(1): 170

P. Senthilraja, K. Kathiresan, In vitro cytotoxicity MTT assay in Vero, HepG2 and MCF -7 cell lines study of Marine Yeast, Journal of Applied Pharmaceutical Science Vol. 5 (03), pp. 080-084, March, 2015.

Anderson Junger Teodoro, Felipe Leite Oliveira, Nathalia Balthazar Martins, Guilherme de Azevedo Maia, Renata Brum Martucci and Radovan Borojevic, Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines, Cancer Cell International, 2012, 12:36.

N. P. C. Fernandes, C. V. Lagishetty, V. S. Panda, and S. R. Naik,

Singh RK, Dhiman RC, Mittal PK, Mosquito larvicidal properties of Momordicacharantia Linn (family: Cucurbitaceae).J Vector Borne Dis. 2006 Jun;43(2):88-91.

D. Singh, V. Bahadur, D. B. Singh, and G. Ghosh,

Downloads

Published

2017-06-01

Issue

Section

Research Articles

How to Cite

1.
Evaluation of Anticancer, Antioxidant and Possible Anti-microbial Properties of extracts of Momordica diocia roots. Int J of Pharm Chem [Internet]. 2017 Jun. 1 [cited 2026 Jan. 3];7(5):74-9. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/4174