The effect of essential oil of Lavandula angustifolia on amyloid beta polymerization: An in vitro study

Authors

  • Masoud Soheili
  • Farzaneh Khalaji
  • Mehdi Mirhashemi
  • Mahmoud Salami

DOI:

https://doi.org/10.7439/ijpc.v7i7.4085

Keywords:

Neonatal septicaemia, Blood culture, Antibiotic susceptibility pattern

Abstract

Alzheimers disease (AD) is a progressive neurological disorder associated with cognitive and memory deficits. Accumulation of amyloid beta (A?) plaques is one of the major causes of AD. Therefore, inhibition of the plaque formation has been aimed to play a preventive role in the disease. Lavender, through some neuroprotective roles such as antioxidant effects, is known to be an effective candidate in treatment of neurodegenerative disorders. In this study using Thioflavin T Measurement and Atomic Force Microscope (AFM) Imaging we evaluated effect of essential oil of lavender on A? polymerization.Thioflavin T Method showed that the essential oil enhances the A? aggregation. The results of AFM method also confirmed it. Our data antagonizes previous results indicating clearing effect of aqueous extract of lavender on A? plaque. It seems that the different combination of essential oil and aqueous extract considerably determines if or not the aggregation occurs.

Downloads

Downloads

Published

2017-07-30

Issue

Vol. 7 No. 7 (2017): Jul

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
  • The author must submit Copyright form After acceptance of the article.

How to Cite

1.
The effect of essential oil of Lavandula angustifolia on amyloid beta polymerization: An in vitro study. Int J of Pharm Chem [Internet]. 2017 Jul. 30 [cited 2025 May 16];7(7):103-7. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/4085
Crossref
Scopus
Google Scholar
Europe PMC