Phytochemical Screening, Spectroscpic Characterisation and Cardiotonic Activity of Aqueous Extract from Arieal Parts of Carmona Retusa (Vahl) Masam on Isolated Frogs Heart

Authors

  • Venkata Pavan Kumar G. University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, A.P http://orcid.org/0000-0002-1554-9907
  • Prameela Rani A. University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, A.P
  • Pooja B. Sims College of Pharmacy, Mangaldas Nagar, Guntur, A.P
  • Anil Kumar Y. Hindu College of Pharmacy, Amaravathi Road, Guntur, A.P

DOI:

https://doi.org/10.7439/ijpc.v6i12.3804

Keywords:

Hypertensive emergency, pregnancy, IV Labetalol, IV Hydralazine, SBP, DBP

Abstract

The present study was undertaken to evaluate cardiotonic activity of aqueous extract of whole plant of carmona retusa (vahl) masam. Phytochemical screening of whole plant material revealed that the major constituent of Carmon retusa (Vahl.) Masam plant is an intractable mixture of alkaloids,triterpenes, flavanoids and cardiac gylcosides. Cardiotonic effect of aqueous extract of whole plant of carmona retusa was studied by using isolated frog heart perfusion technique (IFHP). Calcium free Ringer solution was used as vehicle for administration of aqueous extract of carmona retusa as a test extract and digoxin as a standard. A significant increase in height of force of contraction (positive inotropic effect) and decrease in heart rate (negative chronotropic effect) at a very low concentration (10g/ml) was observed with test extract as compared to the same dose of a standard digoxin. The present results indicated that a significant increase in height of force of contraction with decrease in heart rate was observed as the dose of test extract increased. The test extract does not produced cardiac arrest at 80g/ml, a higher concentration, as compared to standard, digoxin, a drug with narrow therapeutic window, carmona retusa showed wide therapeutic window.

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Author Biography

  • Venkata Pavan Kumar G., University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur, A.P

    PHARMACEUTICAL CHEMISTRY

    RESEARCH SCHOLAR

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Published

2016-12-31

Issue

Vol. 6 No. 12 (2016): Dec

Section

Research Articles

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How to Cite

1.
Phytochemical Screening, Spectroscpic Characterisation and Cardiotonic Activity of Aqueous Extract from Arieal Parts of Carmona Retusa (Vahl) Masam on Isolated Frogs Heart. Int J of Pharm Chem [Internet]. 2016 Dec. 31 [cited 2026 Jan. 3];6(12):230-6. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/3804
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