Synthesis, hypoglycemic and aldose reductase inhibition activity of novel ferulic acid derivatives
DOI:
https://doi.org/10.7439/ijpc.v7i1.3798Abstract
A novel class of ferulic acid derivatives with urea groups were synthesized and evaluated for hypoglycemic and aldose reductase inhibition activities. Several compounds showed comparable in vivo hypoglycemic agents to the commercial drug glibenclamide. Furthermore, of the tested compounds, 7a and 7 b displayed the most potent aldose reductase inhibitory activity in vitro , with an IC 50 of 0.55 and 3.88 M, respectively. Docking simulation was performed to insert compound 7a and 12a into the crystal structure of aldose reductase at active site to determine the probable binding model.Downloads
Download data is not yet available.
Downloads
Published
2017-01-30
Issue
Section
Research Articles
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
- The author must submit Copyright form After acceptance of the article.
How to Cite
1.
Synthesis, hypoglycemic and aldose reductase inhibition activity of novel ferulic acid derivatives. Int J of Pharm Chem [Internet]. 2017 Jan. 30 [cited 2026 Jan. 3];7(1):01-10. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/3798
