Synthesis, in vitro Antibacterial and Cytotoxic studies of novel Naphthofurans

Authors

  • Mathiyazhagan K. Sri Ganesh Labs, 223/A, D-Block, Auto Nagar, Old Gajuwaka, Visakhapatnam 530012
  • Arjun P. Natural Products and Biotechnology Laboratory, Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai-600 025
  • Vennila S.

DOI:

https://doi.org/10.7439/ijpc.v6i9.3606

Keywords:

interactive lecture, medical students, perception, revised medical curriculum

Abstract

A simple, convenient and reproducible naphthofuran derivatives (1-5) were synthesized from 1,4-naphthoquinones and characterized by 1 H-NMR, 13 C-NMR, FT-IR, and Mass spectral studies. All the newly synthesized compounds were evaluated for in vitro antibacterial activity against Staphylococcus aureus (ATCC 6538) , Staphylococcus epidermidis (ATCC 155) and Bacillus cereus (ATCC 11778) as Gram positive bacteria; Escherichia coli (ATCC 25922) , Klebsiella pneumonia (ATCC 29665) and Pseudomonas aeruginosa (ATCC 25619) as Gram negative bacteria and their minimal inhibitory concentrations were determined. Amongst the tested organisms, compound 1 was the most active compound against all the tested organisms. All the compounds were evaluated for in vitro cytotoxicity potential using the standard MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against human cervical cancer cell line (HeLa) and compound 3 showed more potent than other compounds.

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References

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Published

2016-09-30

Issue

Vol. 6 No. 9 (2016): Sep

Section

Research Articles

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How to Cite

1.
Synthesis, in vitro Antibacterial and Cytotoxic studies of novel Naphthofurans. Int J of Pharm Chem [Internet]. 2016 Sep. 30 [cited 2026 Jan. 3];6(9):200-8. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/3606
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