A Novel Synthesis of N-substituted Glutarimides using ZnCl2 Catalyst: A green approach

Abstract

The glutarimides containing piperidine ring is a structural feature of many alkaloids and starting material for drug synthesis. Many piperidine type of compounds are mentioned in clinical and preclinical analysis. The piperidine ring system is one of the commonest structural sub units in natural compounds. Several substituted piperidines display important biological properties like antiviral activity. We have optimised and used a simple ZnCl ₂ catalysed and highly efficient method for the synthesis of 1-(4-chlorophenyl) piperidine-2,6-diones(Glutarimides) using ethanol solvent. The synthesized compounds are used as precursor for 2,6-dichlorodialdehydes 1, 4-DHP[1-2]. All the synthesized glutarimides are characterized by analytical and modern spectral methods such as FTIR, ¹ H-NMR, GC-MS. The resulting compounds possess symmetrical structures and have high yields.