Antibacterial and Antitubercular Activity of Gnidia glauca (Fresn gilg) Root Extracts
DOI:
https://doi.org/10.7439/ijpc.v6i7.3369Keywords:
pancreatitis, intrahepatic, psudocystsAbstract
Antimicrobial properties of medicinal plants are being increasingly reported from different parts of the world. Because of the side effects and the resistance that pathogenic microorganisms that build against antibiotics, many scientists have recently paid attention to extracts and biologically active compounds isolated from medicinal plants. The intention of this study was to evaluate the antibacterial activity of pet-ether, chloroform and ethanol extracts of Gnidia glauca against five Gram-positive bacteria and five Gram-negative bacteria by agar well diffusion method. The zone of inhibition of extracts was compared with standard antibiotics. The results of the study indicated that, the pet-ether and chloroform extracts of the plant were highly effective towards most of the bacterial strains. The ethanol extract showed appreciable activity against B.subtilis and showed a moderate growth inhibitory activity towards all other tested organisms. The organisms which were highly susceptible to extracts were selected for the determination of Minimum Inhibitory Concentration (MIC) by Broth dilution method. When compared to chloroform and ethanol extracts, pet-ether extract has showed a lowest MIC of 1.562 mg/ml against B.subtilis , V.cholerae and 3.125 mg/ml against S.pyogenes . The antitubercular activity of all the extracts of Gnidia glauca have been evaluated against Mycobacterium tuberculosis H 73 Rv strain using Microplate Alamar Blue Assay (MABA). The activity was documented within MIC range of 0.2 to 100g/ml. The results of MABA showed that pet-ether extract exhibited excellent antitubercular activity. The chloroform extract is moderately active, whereas ethanol extract is less active against Mycobacterium tuberculosis . The present investigation suggests that Gnidia glauca posses remarkable antibacterial and antitubercular activity.Downloads
Downloads
Published
2016-07-30
Issue
Section
Research Articles
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
- The author must submit Copyright form After acceptance of the article.
How to Cite
1.
Antibacterial and Antitubercular Activity of Gnidia glauca (Fresn gilg) Root Extracts. Int J of Pharm Chem [Internet]. 2016 Jul. 30 [cited 2025 May 23];6(7):186-91. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/3369