Phytochemical screening and anti-emetic activity of Leonotis nepetifolia leaves extract
DOI:
https://doi.org/10.7439/ijpc.v6i7.3346Abstract
Objectives: Leonotis Nepetifolia (Family: Lamiaceae) is a herb distributed in central and eastern peninsular India which is used as bitter tonic in fevers and also used in pneumonia, flu, mouth and lip infections. The present study focuses on the investigation of antiemetic activity of Leonotis Nepetifolia leaf extract. Method: The study includes preliminary investigation of phytochemical constituents followed by the antiemetic activity of Leonotis Nepetifolia leaf extract on 2-4 days male chicks (32-52gms). Results: The results reveal the presence of bioactive constituents comprising alkaloids, flavonoids, phenolics, tannins, glycosides, steroids and saponins in different solvents and also have antiemetic potential comparable with that of the reference drug Metoclopramide. Ethanol extract of 200 mg/kg inhibited the retches up to 73.761%, which inhibited emesis to an extent equal to Metoclopramide at 50mg/kg. Conclusion: The antiemetic potential of Leonotis Nepetifolia leaf extract may be due to the presence of phytoconstituents like alkaloids and terpenoids.Downloads
References
Bulbul L, Ferdowshi A, Rahman SM, Sushanta MS, Tanni S, Uddin Md. J. In Vitro & In Vivo evaluations of Mikania cordata (Bumr. f.) B.L. Robinson extracts. Indo American Journal of Pharm Research 2013; 3(2): 2230-8.
Cubeddu LX: Mechanisms by which cancer chemotherapeutic drugs induce emesis. Semin Oncol 1992; 19 (6)(15): 2-13,.
Decker, W. J. "In Quest of Emesis: Fact, Fable, and Fancy". Clinical Toxicology 1971; 4 (3): 383
Hasan MMU, Azhar I, Muzammil S, Ahmed S, Ahmed SW., Anti-emetic activity of some leguminous plants. Pakistan Journal of Botany. 2012; 44(1): 389-91.
Miller AD, Leslie RA: The area postrema and vomiting. Front Neuroendocrinol; 1994:15(4): 301-20.
Hornby, PJ. Central neurocircuitry associated with emesis. The American Journal of Medicine. 2001; 111: 8A (8): 106S
Hosseinzadeh H, Mirshojaeian M, Razavi BM. Antiemetic Effect of Pistacia Vera L. (Pistachio) Leaves and Nuts Aqueous Extracts in Young Chicken. Pharmacologyonline. 2008; 2:568-71.
Khandelwal, K., R., Practical Pharmacognosy; Nirali Prakashan, 2006:151-153.
Holtzmann NA, Haslam RH. Elevation of serum copper following copper sulfate as an emetic. Pediatrics1968; 42 (1): 189
Kraisintu, Y, Industrial exploitation of indigenous and medicinal aromatic plants formulation and industrial utilization in UNDP, 1997.
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