Phytochemical screening and anti-emetic activity of Leonotis nepetifolia leaves extract

Authors

  • Jainendra Kumar B. Department of Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur (V), Ranga Reddy (D), Hyderabad. Telangana State
  • Sowjanya Kumar R Department of Chemistry, School of Pharmacy, Anurag Group of Institutions, Venkatapur (V), Ranga Reddy (D), Hyderabad. Telangana State
  • Ramya Deepthi Department of Pharmaceutics, School of Pharmacy, Anurag Group of Institutions, Venkatapur (V), Ranga Reddy (D), Hyderabad. Telangana State
  • Vasudha Bakshi Department of Pharmaceutics, School of Pharmacy, Anurag Group of Institutions, Venkatapur (V), Ranga Reddy (D), Hyderabad. Telangana State

DOI:

https://doi.org/10.7439/ijpc.v6i7.3346

Abstract

Objectives: Leonotis Nepetifolia (Family: Lamiaceae) is a herb distributed in central and eastern peninsular India which is used as bitter tonic in fevers and also used in pneumonia, flu, mouth and lip infections. The present study focuses on the investigation of antiemetic activity of Leonotis Nepetifolia leaf extract. Method: The study includes preliminary investigation of phytochemical constituents followed by the antiemetic activity of Leonotis Nepetifolia leaf extract on 2-4 days male chicks (32-52gms). Results: The results reveal the presence of bioactive constituents comprising alkaloids, flavonoids, phenolics, tannins, glycosides, steroids and saponins in different solvents and also have antiemetic potential comparable with that of the reference drug Metoclopramide. Ethanol extract of 200 mg/kg inhibited the retches up to 73.761%, which inhibited emesis to an extent equal to Metoclopramide at 50mg/kg. Conclusion: The antiemetic potential of Leonotis Nepetifolia leaf extract may be due to the presence of phytoconstituents like alkaloids and terpenoids.

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References

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Published

2016-07-30

Issue

Section

Research Articles

How to Cite

1.
Phytochemical screening and anti-emetic activity of Leonotis nepetifolia leaves extract. Int J of Pharm Chem [Internet]. 2016 Jul. 30 [cited 2025 May 19];6(7):177-80. Available from: https://ssjournals.co.in/index.php/ijpc/article/view/3346